Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of <em>Plasmodium falciparum</em> enoyl-ACP-reductase... (Publications)
terms of inhibitory potency against enzymes of the PfFAS-II pathway. Among the tested compounds, 7 and 8 showed the highest inhibitory potency against Pf enoyl-ACP-reductase (PfFabI), followed by 15 and 3
Antitumoral and antileishmanial dioncoquinones and ancistroquinones from cell cultures of <em>Triphyophyllum peltatum</em> (Dioncophyllaceae) and... (Publications)
l methods. Furthermore, the already known naphthoquinones plumbagin (2), droserone (3), malvone A (8), and nepenthone A (11) were found in the extract of A. abbreviatus. Dioncoquinones A (4) and B (5)
Effect of supervised training on FEV1 in cystic fibrosis: a randomised controlled trial (Publications)
at 6months. RESULTS: FEV1 increased significantly in both training groups compared with CONCH (AT:+5.8±0.95, ST:+7.4±2.5, CONCH:-11.5±2.7% predicted, p
Prevalence of dementia, depression, and mild cognitive impairment in a rural area of the island of Crete, Greece (Publications)
Mungas adjustment, the results were as follows-depression: 33.9%; MCI: 15.3%; MCI with depression: 8.6%; dementia: 2.0%; and dementia with depression: 7.2%. Dementia is less prevalent compared to global
Design, synthesis, and biological evaluation of new 1-(Aryl-1<em>H</em>-pyrrolyl)(phenyl)methyl-1<em>H</em>-imidazole derivatives as antiprotozoal... (Publications)
a number of different protozoa. The mechanism of action for the most potent derivatives (5i, 6a-c, 8b) was assessed by a target-based assays using recombinant T. cruzi CYP51. Bioavailability and efficacy
Rating early child development outcome measurement tools for routine health programme use (Publications)
Recommendations, Assessment, Development and Evaluations. RESULTS: 61 tools were initially identified, 8% (n=5) population-level and 92% (n=56) individual-level screening or ability tests. Of these, 27 tools
Kato-Katz versus urine POC-CCA for the diagnosis of <em>Schistosoma mansoni </em>in preschool-aged children in Homa Bay County, Kenya (Publications)
KK and POC-CCA tests as the "gold standard," the overall sensitivity of KK (57.6%; 95% CI, 49.1-65.8) was significantly lower than that of POC-CCA (73.2%; 95% CI, 65.0-80.4); χm2 = 5.88, p = 0.015. There
Trichuriasis in human patients from Côte d'Ivoire caused by novel <em>Trichuris incognita</em> species with low sensitivity to albendazole/ivermectin... (Publications)
found in Laos and Tanzania and was more closely related to T. suis. Mitochondrial genome sequencing of 8 adult Trichuris worms from Côte d'Ivoire confirmed their species-level differentiation. Sequences from
Lymph node dendritic cells harbor inducible replication-competent HIV despite years of suppressive ART (Publications)
years are transcriptionally silent but harbor replication-competent virus that can be induced upon TLR7/8 stimulation. Taken together, these results uncover a potential important contribution of LN DCs to HIV
Benefit-cost analysis of coordinated strategies for control of rabies in Africa (Publications)
lead to the elimination of dog rabies in Africa with total welfare gains of USD 9.5 billion (95% CI: 8.1 - 11.4 billion) between 2024 and 2054 (30 years). Coordinated disease control between African countries
