<em>In vitro</em>, <em>ex vivo</em> and<em> in vivo</em> activity of diamidines against <em>Trypanosoma congolense</em> and <em>Trypanosoma vivax</em> (Publications)
ex vivo drug sensitivity assays. The IC50 values obtained ranged from 0.007 to 0.562 mug/ml for T. congolense and from 0.019 to 0.607 mug/ml for T. vivax Based on these promising results, 33 of these
Tuberculosis transmission in public locations in Tanzania: a novel approach to studying airborne disease transmission (Publications)
markets (4.8% for traders, but 0.5% for their customers), passengers on public transport (2.4%), public schools (4.0%), nightclubs (1.7%), religious (0.13%), and social halls (0.12%). CONCLUSION: For the first
Molecular epidemiology and whole genome sequencing analysis of clinical <em>Mycobacterium bovis</em> from Ghana (Publications)
of published M. bovis genomes. RESULTS: Mycobacterium bovis was isolated from 3/560(0.5%) females and 12/1195(1.0%) males with pulmonary TB. The average age of M. bovis infected cases was 46.8 years [...] (1.9%;4/212) had a higher rate of infection with M. bovis (OR = 2.7,p = 0.0968) compared to those from the Greater Accra region (0.7%;11/1543). Among TB patients with available HIV status, the odds of isolating
Public health impact of current and proposed age-expanded perennial malaria chemoprevention: a modelling study (Publications)
and PMC+'s median efficacy (interquartile range) of 18.6% (12.2-25.0%) and 21.9% (14.3-29.5%) against clinical disease and 9.0% (2.0-16.0%) and 10.8% (3.2-18.4%) against severe malaria, respectively, in
Spatial analysis of schistosomiasis in Hunan and Jiangxi provinces in the People's Republic of China (Publications)
iasis varied at pixel level (0.1 x 0.1 km), and was significantly associated with distance to nearest waterbody (km, beta = -1.158; 95% credible interval [CrI]: -2.104, -0.116) in Hunan and temperature [...] e ( degrees C, beta = -4.359; 95% CrI: -9.641, -0.055) in Jiangxi. The spatial distribution of schistosomiasis in Hunan and Jiangxi varied substantially and was significantly associated with distance to
Stringency of COVID-19 containment response policies and air quality changes: a global analysis across 1851 cities (Publications)
ly during moderate CRPs and even increased during mild CRPs by 2.3% (95% CI: 0.7, 4.0%), which was 6.8% (95% CI: 2.0, 12.0%) across Europe and Central Asia, possibly due to population avoidance of public
Amyotrophic lateral sclerosis, occupational exposure to extremely low frequency magnetic fields and electric shocks: a systematic review and... (Publications)
of publication bias (PEgger's test=0.03). No association was observed between occupational exposure to electric shocks and risk of ALS (RRPooled estimate: 0.97; 95%CI: 0.80, 1.17) with high heterogeneity [...] y (I2=80.5%), and little indication for publication bias (PEgger's test=0.24). The findings indicate that occupational exposure to ELF-MF, but not electric shocks, might be a risk factor for ALS. However
Validation of two accelerometers to determine mechanical loading of physical activities in children (Publications)
increasing locomotion speed and landing height (P < 0.001). Data from ACT and GEN correlated with GRF (r = 0.90 and 0.89, respectively) and between each other (r = 0.98), but both accelerometers consistently o
Reduced risk of <em>Plasmodium vivax</em> malaria in Papua New Guinean children with Southeast Asian ovalocytosis in two cohorts and a case-control... (Publications)
reduction in the incidence of clinical P. vivax episodes (adjusted incidence rate ratio [IRR] = 0.54, 95% CI 0.40-0.72, p 90% binding inhibition) P. vivax Duffy binding protein-specific binding inhibitory antibodies [...] observed significantly more often in sera from SAO than non-SAO children (SAO, 22.2%; non-SAO, 6.7%; p = 0.008). CONCLUSIONS: In three independent studies, we observed strong associations between SAO and protection
A high force of <em>Plasmodium vivax</em> blood-stage infection drives the rapid acquisition of immunity in Papua New Guinean children (Publications)
The incidence of P. vivax showed a faster decrease with age in children with high (IRR = 0.49, CI95 [0.38, 0.64] p [...] episodes decreased three-fold over the age range of 1-4.5 years. RESULTS: On average, children acquired 14.0 new P. vivax blood-stage clones/child/year-at-risk. While the incidence of clinical P. vivax illness
