Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of <em>Plasmodium falciparum</em> enoyl-ACP-reductase... (Publications)
terms of inhibitory potency against enzymes of the PfFAS-II pathway. Among the tested compounds, 7 and 8 showed the highest inhibitory potency against Pf enoyl-ACP-reductase (PfFabI), followed by 15 and 3
Antitumoral and antileishmanial dioncoquinones and ancistroquinones from cell cultures of <em>Triphyophyllum peltatum</em> (Dioncophyllaceae) and... (Publications)
l methods. Furthermore, the already known naphthoquinones plumbagin (2), droserone (3), malvone A (8), and nepenthone A (11) were found in the extract of A. abbreviatus. Dioncoquinones A (4) and B (5)
Effect of supervised training on FEV1 in cystic fibrosis: a randomised controlled trial (Publications)
at 6months. RESULTS: FEV1 increased significantly in both training groups compared with CONCH (AT:+5.8±0.95, ST:+7.4±2.5, CONCH:-11.5±2.7% predicted, p
Prevalence of dementia, depression, and mild cognitive impairment in a rural area of the island of Crete, Greece (Publications)
Mungas adjustment, the results were as follows-depression: 33.9%; MCI: 15.3%; MCI with depression: 8.6%; dementia: 2.0%; and dementia with depression: 7.2%. Dementia is less prevalent compared to global
Design, synthesis, and biological evaluation of new 1-(Aryl-1<em>H</em>-pyrrolyl)(phenyl)methyl-1<em>H</em>-imidazole derivatives as antiprotozoal... (Publications)
a number of different protozoa. The mechanism of action for the most potent derivatives (5i, 6a-c, 8b) was assessed by a target-based assays using recombinant T. cruzi CYP51. Bioavailability and efficacy
Rating early child development outcome measurement tools for routine health programme use (Publications)
Recommendations, Assessment, Development and Evaluations. RESULTS: 61 tools were initially identified, 8% (n=5) population-level and 92% (n=56) individual-level screening or ability tests. Of these, 27 tools
Glycaemic control among patients with type 2 diabetes followed in a rural African primary care setting - a reality check in the Democratic Republic of... (Publications)
(212 men, 107 women) were enrolled. The target threshold of HbA1c level at 7.0% or below was met by 17.8% (19/107) of female and 12.3% (26/212) of male patients. The fasting plasma glucose level was
The viral load monitoring cascade in a resource-limited setting: a prospective multicentre cohort study after introduction of routine viral load... (Publications)
L unsuppressed. Patients with unsuppressed VL receive adherence counseling and follow-up VL within 8-12 weeks. Two consecutively unsuppressed VLs should trigger switch to second-line ART. For analysis
The age profile of respiratory syncytial virus burden in preschool children of low- and middle-income countries: a semi-parametric, meta-regression... (Publications)
burden of RSV in all low- and middle-income countries. The peak age of community-based incidence is 4.8 months, and the mean and median age of infection is 18.9 and 14.7 months, respectively. Estimating the [...] profile, in which the peak age of infection is 2.6 months and the mean and median age of infection are 15.8 and 11.6 months, respectively. More severe outcomes, such as hospitalization and in-hospital death have
Pharmacokinetics of ivermectin metabolites and their activity against <em>Anopheles stephensi </em>mosquitoes (Publications)
RESULTS: Human CYP3A4 metabolised ivermectin more rapidly than CYP3A5. Ivermectin metabolites M1-M8 were predominantly formed by CYP3A4, whereas metabolite M9 (hydroxy-H(2)B(1a)) was mainly produced by [...] (57.5 +/- 13.2 h) were considerably longer than that of the parent compound ivermectin (38.9 +/- 20.8 h). CONCLUSION: In conclusion, the ivermectin metabolites M1 and M2 contribute to the activity of ivermectin
