Fine-scale-mapping of <em>Schistosoma haematobium</em> infections at the school and community levels and intermediate host snail abundance in the... (Publications)
haematobium prevalence was 1.2% (26/2196) in school-aged children and 0.8% (31/3893) in community members, with 0.2% (4/2196) and 0.1% (3/3893) heavy-intensity infections, respectively. Children who studied [...] [OR]: 5.0; 95% confidence interval [CI]: 2.3-11.1). Individuals living in a house located < 1 km away from HWCSs with B. globosus had higher odds than those residing in > 2 km distance (OR: 18.0; 95% CI: [...] CI: 2.9-111.0). Self-reported praziquantel treatment coverage was 83.2%...
Comparison of cone bioassay estimates at two laboratories with different <em>Anopheles </em>mosquitoes for quality assurance of pyrethroid... (Publications)
Results from IHI and PNGIMR correlated on 60-min knockdown (KD60) (rs = 0.6,p = 0.002,n = 20) and 24-h mortality (M24) (rs = 0.9,p < 0.0001,n = 20) but BA showed systematic bias between the results. Of the [...] these as a pass, the agreement between the results to predict ITN failure was good with kappa = 0.79 (0.53-1.00) and 90% accuracy. CONCLUSIONS: Based on these study findings, the WHO cone bioassay is a
Safety, immunogenicity and efficacy of PfSPZ vaccine against malaria in infants in western Kenya: a double-blind, randomized, placebo-controlled phase... (Publications)
the 9.0 x 10(5) dose group = -6.5%, P = 0.598, the primary statistical end point of the study). VE against clinical malaria 3 months after the last dose in the highest-dose group was 45.8% (P = 0.027), [...] 3-related solicited AE in the vaccine group (0.4%) and 2 in the placebo group (2.4%). Seizures were more common in the highest-dose group (14.3%) compared to 6.0% of controls, with most being attributed to [...] malaria setting in western Kenya ( NCT02687373 ). Groups of 84 infants each...
Associations of air pollution and greenness with mortality in Greece: an ecological study (Publications)
natural-cause (RR 0.95, 95% CI: 0.94, 0.96 per IQR) and cause-specific mortality. For all outcomes we estimated a protective association with O3 (natural-cause mortality RR 0.79, 95% CI: 0.76, 0.82 per IQR)
Impact of road traffic noise on obesity measures: observational study of three European cohorts (Publications)
In UK Biobank, per 10 dB(A) higher of Lden: BMI was higher by 0.14kg/m2(95%CI: 0.11-0.18), waist circumference higher by 0.27cm(95%CI: 0.19-0.35), odds of obesity was 1.06(95%CI: 1.04-1.08) and of central
Validation of quantitative scores derived from motor evoked potentials in the assessment of primary progressive multiple sclerosis: a longitudinal... (Publications)
rANOVA model (p < 0.05; post-hoc comparison baseline-year 2, p < 0.1). Lower limb and combined qMEP scores showed significant deterioration of latency (p < 0.01, MEP-LL_CxM-sh: p < 0.05) and in post-hoc [...] post-hoc comparisons (baseline-year 2, p < 0.05), qMEP_CxM-mn even over 1 year (p < 0.05). Effect sizes were higher for qMEP scores than for clinical measures, and slightly but consistently higher when based
A single LC-tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma (Publications)
formate 20mM (pH 4.0) 1:1. Reverse-phase chromatographic separation of antimalarial drugs is obtained using a gradient elution of 20mM ammonium formate and acetonitrile both containing 0.5% formic acid, followed [...] of 0.2% hemolysed red-blood cells in plasma, whereas its derivatives were essentially not affected. The method is precise (inter-day CV%: 3.1-12.6%) and sensitive (lower limits of quantification 0.15-3 [...] 15-3.0 and 0.75-5ng/ml for basic/neutral antimalarials and artemisinin...
Air pollution in Switzerland: quantification of health effects using epidemiologic data (Publications)
admissions for respiratory diseases (+1.47% +/-0.5/71 +/-24 additional admissions or 1,104 (+/-390) hospital days); admissions for cardiovascular diseases (+0.9% +/-0.25/70 +19 admissions; 970 (+/-270) hospital [...] hospital days); restricted activity days (+10.5% +/-0.77/0.42 +/-0.03 million person-days); days with asthma attacks among the 6.7% asthmatics (Swiss prevalence) (+5.3% +/-2.1/ 240,000 +/-102,000 additional
Few associations between high-sensitivity C-reactive protein and environmental factors in 4.5-year-old children (Publications)
spending time in stables was associated with reduced hsCRP (15 min-10 h aOR 0.40 95% CI 0.16-0.96 and > /=10 h aOR 0.25 95% CI 0.07-0.90), and among sensitized children, maternal smoking was associated with
Pet-keeping in childhood and adult asthma and hay fever: European community respiratory health survey (Publications)
who had owned dogs in childhood had less hay fever (OR = 0.85; 95% CI = 0.73-0.98) and no increased risk of asthma (OR(wheeze) = 1.01, 95% CI = 0.87-1.17). Respiratory symptoms were more common in subjects [...] 1.31-2.57; 40%-60% cats: OR(wheeze) = 1.33, 95% CI = 1.10-1.61; > or =60% cats: OR(wheeze) = 0.98, 95% CI = 0.73-1.33). Dogs owned in childhood or adulthood were associated with asthma among nonatopic subjects
