Immediate surgery compared with short-course neoadjuvant gemcitabine plus capecitabine, FOLFIRINOX, or chemoradiotherapy in patients with borderline... (Publications)
groups: immediate surgery; neoadjuvant gemcitabine and capecitabine (gemcitabine 1000 mg/m(2) on days 1, 8, and 15, and oral capecitabine 830 mg/m(2) twice a day on days 1-21 of a 28-day cycle for two cycles); [...] neoadjuvant capecitabine-based chemoradiation (total dose 50.4 Gy in 28 daily fractions over 5.5 weeks [1.8 Gy per fraction, Monday to Friday] with capecitabine 830 mg/m(2) twice daily [Monday to Friday] throughout [...] patients who underwent immediate surgery and those who...
The effects and contribution of childhood diseases on the geographical distribution of all-cause under-five mortality in Uganda (Publications)
27% of Ugandan children aged 6-59months were severely or moderately anaemic; lowest in South-West (8%) and highest in East-Central (46%). Overall, 17% of children were either severely or moderately ma [...] percentage of moderately/severely malnourished children varied by region with Kampala having the lowest (8%) and North-East the highest (45%). Nearly a quarter of the children under-five years were reported [...] (PAF=96.9; 95%BCI: 94.4, 98.0), 91% (PAF=90.9; 95%BCI: 84.4, 95.3), 89%...
Immediate surgery compared with short-course neoadjuvant gemcitabine plus capecitabine, FOLFIRINOX, or chemoradiotherapy in patients with borderline... (Publications)
groups: immediate surgery; neoadjuvant gemcitabine and capecitabine (gemcitabine 1000 mg/m(2) on days 1, 8, and 15, and oral capecitabine 830 mg/m(2) twice a day on days 1-21 of a 28-day cycle for two cycles); [...] neoadjuvant capecitabine-based chemoradiation (total dose 50.4 Gy in 28 daily fractions over 5.5 weeks [1.8 Gy per fraction, Monday to Friday] with capecitabine 830 mg/m(2) twice daily [Monday to Friday] throughout [...] patients who underwent immediate surgery and those who...
The effects and contribution of childhood diseases on the geographical distribution of all-cause under-five mortality in Uganda (Publications)
27% of Ugandan children aged 6-59months were severely or moderately anaemic; lowest in South-West (8%) and highest in East-Central (46%). Overall, 17% of children were either severely or moderately ma [...] percentage of moderately/severely malnourished children varied by region with Kampala having the lowest (8%) and North-East the highest (45%). Nearly a quarter of the children under-five years were reported [...] (PAF=96.9; 95%BCI: 94.4, 98.0), 91% (PAF=90.9; 95%BCI: 84.4, 95.3), 89%...
Detection of pathogens of acute febrile illness using polymerase chain reaction from dried blood spots (Publications)
for malaria diagnosis. For other pathogens investigated, DBS testing yielded a sensitivity of only 8.5% but a specificity of 98.6% compared with whole blood qPCR. In sum, direct PCR of DBS had reasonable
Enantiospecific antitrypanosomal<em> in vitro</em> activity of eflornithine (Publications)
50% inhibitory concentrations of the three strains combined were 9.1 muM (95% confidence interval [8.1; 10]), 5.5 muM [4.5; 6.6], and 50 muM [42; 57] for racemic eflornithine, L-eflornithine and D-eflornithine
Synthesis and biological evaluation of natural-product-inspired, aminoalkyl-substituted 1-benzopyrans as novel antiplasmodial agents (Publications)
of the basic amino moiety toward both aromatic rings were varied systematically. 1-Benzopyran-5-ol 8b (IC50 = 10 nM), 1-benzopyran-7-ol 9c (IC50 = 38 nM), and the aminoalcohol 19c (IC50 = 17 nM) displayed
Activities of quinoxaline, nitroquinoxaline and [1,2,4]triazolo[4,3-a]quinoxaline analogs of MMV007204 against <em>Schistosoma mansoni</em> (Publications)
against NTS and adult S. mansoni yielded three compounds with 50% inhibitory concentrations (IC50s) of /= 8.9. Administration of these compounds as a single oral dose of 400 mg/kg of body weight to S. mansoni
Speech and language sequelae of severe malaria in Kenyan children (Publications)
semantics, higher level language abilities, pragmatics and phonology were administered to each child at 8-9 years of age, at least 2 years after admission to hospital in children exposed to severe malaria.
Planning a family: priorities and concerns in rural Tanzania (Publications)
fertility survey using qualitative and quantitative techniques described a high fertility setting (TFR 5.8) in southern Tanzania where family planning use was 16%. Current use was influenced by rising parity
