A novel barcoded nanopore sequencing workflow of high-quality, full-length bacterial 16S amplicons for taxonomic annotation of bacterial isolates and... (Publications)
identification (positive predictive value = 0.90, Cramér's V = 0.857, and Theil's U = 0.316). For species-level community profiling, we found strong correlations (r(s) > 0.6) of alpha diversity indices between [...] strong correlation when comparing the relative abundances of individual species (average r(s) = 0.6 and 0.533 for primers A and B). Despite identified shortcomings, the proposed workflow enabled accurate
Resistance-informed versus empirical management of viraemia in children and adolescents with HIV in Lesotho and Tanzania (GIVE MOVE trial): a... (Publications)
and 73 (52%) in the usual care group (adjusted odds ratio 0·79 [95% CI 0·49 to 1·27]; adjusted risk difference -0·06 [95% CI -0·17 to 0·06]; p=0·34); all participants reaching the composite primary endpoint
Head-to-head comparison of the WHO STEPwise approach with immediate unattended and delayed unattended automated blood pressure measurements during... (Publications)
mean diastolic first uABP (mean difference: -1 mmHg; 95% CI: -2.0 to 0.3); and mean diastolic second uABP (mean difference: 1.0 mmHg; 95% CI: -0.4 to 2.3). White coat hypertension was highest with SBPM (55 [...] CI: 74-85]). This difference was significant between first uABP and SBPM (P = 0.0024), and between second uABP and SBPM (P = 0.0017). INTERPRETATION: uABP had better diagnostic performance than SBPM. Integration
Clinical trial evidence supporting US Food and Drug Administration approval of novel cancer therapies between 2000 and 2016 (Publications)
were for solid tumors. Novel drugs had mean hazard ratios of 0.77 (95% CI, 0.73-0.81; I2 = 46%) for overall survival and 0.52 (95% CI, 0.47-0.57; I2 = 88%) for progression-free survival. The median tumor
Significant geographical differences in prevalence of mutations associated with <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> drug... (Publications)
pfcrt SVMNT (97.4 vs 83.3 %, p = 0.001), pfdhfr (59R-108 N) (100 vs 90.6 %, p = 0.001), pvdhfr haplotypes (75.8 vs 47.6 %, p = 0.001) and pvmdr1 976F (71.2 vs 26.2 %, p < 0.001). Data from a subsequent Madang [...] of pfdhps mutations increased significantly from 30 % (p < 0.001) as did the prevalence of pvdhfr mutant haplotypes (from 75.8 to 97.4 %, p = 0.012). CONCLUSIONS: This LDR-FMA multiplex platform shows
Maternal HIV and drug use: effect on health and social morbidity (Publications)
maternal drug use exerting a negative influence on outpatient visits (odds ratio 0.6, 95% confidence interval 0.4 to 1.0). At 6 weeks, the majority of children lived with their birth parent(s), and no
HIV infection disrupts the sympatric host-pathogen relationship in human tuberculosis (Publications)
interval [95% CI] 1.21-infinity, p = 0.03). HIV infection was significantly associated with TB caused by an allopatric (as opposed to sympatric) M. tuberculosis lineage (OR 7.0, 95% CI 2.5-19.1, p [...] 2008 in Switzerland. We analyzed 518 TB patients of whom 112 (21.6%) were HIV-infected and 233 (45.0%) were born in Europe. We found that among European-born TB patients, recent transmission was more likely
<em>In vitro</em> metabolic profile and <em>in vivo</em> antischistosomal activity studies of (n6-praziquantel)Cr(Co)3 derivatives (Publications)
activity was observed. The R-enantiomers are highly active against adult schistosomes in vitro (IC50 0.08-0.13 ?M), whereas both S-enantiomers lack activity. The in vivo activity of 1 and 2 was then studied [...] infection. A single dose of 1 and 2 (400 mg/kg) resulted in low worm burden reductions of 24% and 29% (p > 0.05).
Eleganolone, a Diterpene from the French marine alga <em>Bifurcaria bifurcata</em> inhibits growth of the human pathogens <em>Trypanosoma brucei</em>... (Publications)
contributes only mildly to the trypanocidal activity of the ethyl acetate extract (IC(50) = 45.0 microM, SI = 4.0). However, a selective activity against P. falciparum erythrocytic stages in vitro has been [...] Bifurcaria bifurcata, showed strong trypanocidal activity with a mild selectivity index (IC(50) = 0.53 microg/mL; selectivity index (SI) = 11.6). Bio-guided fractionation led to the isolation of eleganolone
Effects of a school-based physical activity program on physical and psychosocial quality of life in elementary school children: a cluster-randomized... (Publications)
size [d], 0.32; p < .05). Subpopulation analyses revealed that this effect was caused by an effect in urban (effect size [d], 0.38; p < .05) and overweight first graders (effect size [d], 0.45; p < .05)
