The antiprotozoal activity of sixteen asteraceae species native to Sudan and bioactivity-guided isolation of xanthanolides from <em>Xanthium... (Publications)
xanthanolide series (4,5-seco-guaianolide-type). They were identified by spectroscopic means as 8-epixanthatin ( 1), 8-epixanthatin 1beta,5beta-epoxide ( 2), and as the dimers pungiolide A ( 4) as well as pungiolide [...] xanthanolide sesquiterpene lactones, xanthipungolide ( 3) and 4,15-dinor-1,11(13)-xanthadiene-3,5beta:12,8beta-diolide ( 6) were isolated. While xanthipungolide turned out to be inactive against the tested parasites [...] most notably, on their antiprotozoal activity. As the...
No <em>Paragonimus</em> in high-risk groups in Côte d'Ivoire, but considerable prevalence of helminths and intestinal protozoon infections (Publications)
complete data records, 62 had tuberculosis, with a higher prevalence in males than females (28.8% vs. 13.9%, chi2 = 8.79, p = 0.003). The prevalence of helminths and intestinal protozoa was 4.6% and 16.9%, [...] sis was diagnosed. However, trematode infections were seen in 32 of the 272 shellfish examined (11.8%). Questionnaire results revealed that crab and pig meat is well cooked before consumption. Among the [...] children with complete data records, the prevalence of helminths and...
Somatostatin-based radiotherapy with [90Y-DOTA]-TOC in neuroendocrine tumors: long-term outcome of a phase I dose escalation study (Publications)
9-7.8 GBq/cycle), 77 patients were enrolled for intermediate dose (median: 3.3 GBq/cycle, range: 2.0-7.4 GBq/cycle) and 222 patients were enrolled for high dose (median: 6.7 GBq/cycle, range: 3.7-8.1 GBq/cycle) [...] The incidences of hematotoxicities grade 1--4 were 65.0%, 64.9% and 74.8%; the incidences of grade 4/5 kidney toxicities were 8.4%, 6.5% and 14.0%, and the median survival was 39 (range: 1--158) months [...] high dose protocol was associated with an increased risk of kidney...
The antiprotozoal activity of sixteen asteraceae species native to Sudan and bioactivity-guided isolation of xanthanolides from <em>Xanthium... (Publications)
xanthanolide series (4,5-seco-guaianolide-type). They were identified by spectroscopic means as 8-epixanthatin ( 1), 8-epixanthatin 1beta,5beta-epoxide ( 2), and as the dimers pungiolide A ( 4) as well as pungiolide [...] xanthanolide sesquiterpene lactones, xanthipungolide ( 3) and 4,15-dinor-1,11(13)-xanthadiene-3,5beta:12,8beta-diolide ( 6) were isolated. While xanthipungolide turned out to be inactive against the tested parasites [...] most notably, on their antiprotozoal activity. As the...
Who is best to test? A systematic review of chlamydia infections in Switzerland (Publications)
Chlamydia prevalence ranged between 0.8 and 12.8%. Most frequently affected were undocumented women undergoing voluntary termination of pregnancy (12.8%, 95% CI: 8.4-18.9), HIV-positive men who have sex
Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents (Publications)
guanidine intermediates 8a-f which can also be regarded as potential prodrugs for the guanidino derivatives. Compounds 9c-f were obtained via the base catalyzed decarbamoylation of 8a-f. The DNA binding [...] not yield cures upon oral administration in the antitrypanosomal STIB900 mouse model, compounds 8a and 8c prolonged the survival of the treated mice
Changes in active and passive smoking in the European Community Respiratory Health Survey (Publications)
participated in the European Community Respiratory Health Survey II. The mean follow-up period was 8.8 yrs. Change in the prevalence of active and passive smoking was expressed as absolute net change (95% [...] ratio (OR). The prevalence of active smoking declined by 5.9% (5.1-6.8) and exposure to passive smoking in nonsmokers declined by 18.4% (16.8-20.0). Subjects with a lower educational level (HRR: 0.73 (0.54-0
Phagocytosis of <em>Mycobacterium ulcerans</em> in the course of rifampicin and streptomycin chemotherapy in Buruli ulcer lesions (Publications)
untreated lesions and lesions treated for 8 weeks. METHODS: Tissue specimens were collected from patients who had no treatment and from patients after 4 and 8 weeks of R/S treatment. The main features [...] disease called Buruli ulcer (BU). Currently, dual therapy with rifampicin and streptomycin (R/S) for 8 weeks as well as surgery are the standard treatments. OBJECTIVES: To elucidate the processes taking [...] covering the whole lesion had developed in a nodular lesion. In contrast, ulcerative...
Spatial and temporal variability of fluoride concentrations in groundwater resources of Larestan and Gerash regions in Iran from 2003 to 2010 (Publications)
mean concentrations of fluoride for the 8-year period in the eight cities and 31 villages were 1.6 and 2.0 mg/l, respectively; the maximum values were 2.4 and 3.8 mg/l, respectively. Spatial, temporal, [...] villages for the 8-year period. Specifically, one city and three villages showed positive significant Kendall's Tau values, suggesting an upward trend in fluoride concentrations over the 8-year period. In
Accelerated decline in lung function in smoking women with airway obstruction: SAPALDIA 2 cohort study (Publications)
in FEV1 was -10.4 mL(95%CI -15.3, -5.5) per pack per day between assessments in men and -13.8 mL(95%CI-19.5,-8.1) in women. Decline per pack per day between 1991 and 2002 was lower in women who smoked in [...] compared to persistent smokers (-6.4 vs -11.6 mL, p = 0.05) but this was not seen in men (-14.3 vs -8.8 mL p = 0.49). Smoking related decline was accelerated in men and women with airway obstruction, pa
