FlexiChip package: an universal microarray with a dedicated analysis software for high-thoughput SNPs detection linked to anti-malarial drug... (Publications)
gave results identical to the ResMalChip results in 92.7% of samples (kappa coefficient 0.8491, with a standard error 0.021) and had a sensitivity of 95.88% and a specificity of 97.68% compared to the sequencing [...] results obtained in the reference laboratories, with 99.7% of identical results (kappa coefficient 0.9923, S.E. 0.0523). CONCLUSION: Microarrays could be employed to monitor P. falciparum drug resistance markers
<em>Plasmodium vivax</em> populations are more genetically diverse and less structured than sympatric <em>Plasmodium falciparum</em> populations (Publications)
sympatric P. falciparum isolates. The genetic diversity of P. vivax (He = 0.83-0.85) was higher than that of P. falciparum (He = 0.64-0.77) in all four populations. Moderate levels of genetic differentiation
Force of infection is key to understanding the epidemiology of <em>Plasmodium falciparum</em> malaria in Papua New Guinean children (Publications)
children using ITNs (incidence rate ratio, 0.49; 95% confidence interval, [0.38, 0.61]), increased with age, and significantly varied within villages (P = 0.001). The acquisition of new parasite clones
Role of current and childhood exposure to cat and atopic sensitization (Publications)
particularly among those with a positive family history of atopy (odds ratio 95% confidence interval 0.68 0.51-0.93. Positive correlations were found between the community prevalence of cat and the prevalences [...] interviewer-led questionnaire. RESULTS: The prevalence of sensitization to cat (serum specific IgE > 0.35 kU/L) was 9%. Among those who did not report allergic symptoms in the presence of pets or house dust
Discovery and evaluation of thiazinoquinones as anti-protozoal agents (Publications)
found to exhibit cytotoxicity, carboxylic acid analogues exhibited potent anti-Pf activity (IC50 0.34-0.035 muM) combined with excellent selectivity (SI 560-4000). In vivo evaluation of a furan carboxylic [...] anti-protozoal activity and selectivity. Little variation in anti-malarial potency was observed (IC50 0.62-6.5 muM), and no correlation was apparent between anti-malarial and anti-T. brucei activity. Phe [...] slightly enhanced selectivity (SI 72 and 93, respectively), while...
Environmental and socio-economic risk modelling for Chagas disease in Bolivia (Publications)
c (ROC) area under the curve (AUC) (0.69 AUC, 0.67 AUC and 0.62 AUC, respectively), while areas with hardwood floors demonstrated a direct negative relationship (-0.71 AUC). This study demonstrates that
Bone mineral density and its determinants in men with opioid dependence (Publications)
106), 29.2 % of individuals were osteoporotic (mean T-score -3.0 +/- 0.4 SD) and 48.1 % were diagnosed with osteopenia (mean T-score -1.7 +/- 0.4 SD). In younger men (n = 38), 65.8 % of men had low bone mass [...] analyses, serum free testosterone (fT) was significantly associated with low BMD at the lumbar spine (p = 0.02), but not at the hip. When analysed by quartiles of fT, lumbar spine BMD decreased progressively
Multiplicity of <em>Plasmodium falciparum</em> infection following intermittent preventive treatment in infants (Publications)
life, and increased to 2.57 at age 15 months (P = 0.01). At no age did MOI differ between the IPTi-SP and placebo groups (each, P [greater than or equal to] 0.5). At 15 months of age, i.e., six months after [...] children who had received IPTi or placebo (means, 2.25 vs. 2.33; P = 0.55) as was the proportion of polyclonal infections (69.6% vs. 69.7%; P = 0.99). Adjusting for study site, current and prior malaria, parasite
An integrated and comprehensive service delivery model to improve pediatric and maternal HIV care in rural Africa (Publications)
CD4% (16 vs. 16.8, P = 0.08) and more advanced disease (World Health Organization stage 3/4 72% vs. 35%, P < 0.001). The antiretroviral treatment coverage rose from 80% to 98% (P < 0.001), the lost-to-follow-up [...] llow-up rate decreased from 20% to 11% (P = 0.002), and mortality ascertainment improved. During 2013-2014, 261 HIV-exposed infants were enrolled, and the early mother-to-child transmission rate among
Tuberculosis treatment outcomes among HIV/TB-coinfected children in the International Epidemiology Databases to Evaluate AIDS (IeDEA) network (Publications)
unfavorable outcomes (40%) (P = 0.04). Neither diagnostic modality (odds ratio 1.77; 95% confidence interval: 0.86 to 3.65) nor IP regimen (odds ratio 0.88; 95% confidence interval: 0.43 to 1.80) was associated
