Resource use and costs of investigator-sponsored randomised clinical trials in Switzerland, Germany and the United Kingdom: a meta-research study (Publications)
[IQR, 8.5% to 19.3%] with little variation across countries. The items that contributed most to the total costs were protocol writing (7.2%; IQR 3.8% to 10.6%), data management (5.0%; IQR 2.2% to 8.1%) and [...] intervention types. RESULTS: We included 93 RCTs which were initiated in Switzerland (n=53; including 8 conducted in low- and lower middle-income countries), Germany (n=22), and the UK (n=18). The median [...] and follow up (4.5%; IQR 2.3% to 8.4%). Of the 66 RCTs with an available...
Prepregnancy depression and breastfeeding duration: a look at maternal age (Publications)
dichotomized while breastfeeding duration was categorized as never breastfed, breastfed 8 weeks or less, and breastfed more than 8 weeks. Maternal age was a significant effect modifier; therefore, results were [...] 25-29, and 30-34 years with prepregnancy depression, the odds of never breastfeeding and breastfeeding 8 weeks or less were significantly higher than in women with no history of prepregnancy depression. Notably [...] among women aged 25-29 with prepregnancy depression, the odds of...
HPLC-based activity profiling for antiprotozoal compounds in <em>Croton gratissimus</em> and <em>Cuscuta hyalina</em> (Publications)
(2) exhibited moderate antileishmanial (IC50, 8.2 µM; SI, 12.2), antiplasmodial (IC50, 7.8 µM; SI, 12.9), and antitrypanosomal activity (IC50, 11.2 µM; SI, 8.9). None of the compounds showed notable activity [...] flavonoids 1–6, 3-methoxy-4-hydroxybenzoic acid (7), and benzyltetrahydroisoquinoline alkaloids laudanine (8) and laudanosine (9) from C. gratissimus, and pinoresinol (10), isorhamnetin (11), (-)-pseudosemiglabrin
HIV infection in women: immunological markers and the influence of pregnancy (Publications)
there being no influence of pregnancy on either CD4% or CD8%. CONCLUSIONS: In asymptomatic HIV infection, changes in the absolute levels of CD4 and CD8 lymphocyte counts are primarily related to changes in [...] n and post-pregnancy changes in immunological markers: an increase in the CD4% and a decrease in CD8%. However, causality cannot be implied as pregnancy itself may be associated with considerable lifestyle [...] in the other components of the white cell count because there were no...
Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B3 and B4, and related 5,80'-coupled monomeric alkaloids, ikelacongolines A–D, from a... (Publications)
(4), and four related 5,8′-linked monomeric alkaloids, named ikelacongolines A–D (5a, 5b, 6, and 7). The dimers 3 and 4 are structurally unusual quateraryls comprising two 5,8′-coupled monomers linked [...] liana, three of them belonging to the subclass of 5,8′-coupled naphthylisoquinoline alkaloids, whereas two compounds exhibited a less frequently occurring 7,8′-biaryl linkage. The stereostructures of the new
Efficacy and safety of ascending dosages of moxidectin and moxidectin-albendazole against <em>Trichuris trichiura</em> in adolescents: a randomized... (Publications)
list T. trichiura infected adolescents were randomly assigned to 7 treatment arms: 8, 16 or 24 mg moxidectin monotherapy or 8, 16, 24 mg moxidectin plus 400 mg albendazole combination therapy or placebo. The [...] of 290 adolescents were enrolled (41 or 42 per arm). CRs against T. trichiura were 43, 46, 44% for 8, 16 and 24 mg of moxidectin alone and 60, 62 and 66% for the same moxidectin dosages plus 400 mg of [...] . There is no benefit of increasing the moxidectin dose. The...
Prepregnancy depression and breastfeeding duration: a look at maternal age (Publications)
dichotomized while breastfeeding duration was categorized as never breastfed, breastfed 8 weeks or less, and breastfed more than 8 weeks. Maternal age was a significant effect modifier; therefore, results were [...] 25-29, and 30-34 years with prepregnancy depression, the odds of never breastfeeding and breastfeeding 8 weeks or less were significantly higher than in women with no history of prepregnancy depression. Notably [...] among women aged 25-29 with prepregnancy depression, the odds of...
HPLC-based activity profiling for antiprotozoal compounds in <em>Croton gratissimus</em> and <em>Cuscuta hyalina</em> (Publications)
(2) exhibited moderate antileishmanial (IC50, 8.2 µM; SI, 12.2), antiplasmodial (IC50, 7.8 µM; SI, 12.9), and antitrypanosomal activity (IC50, 11.2 µM; SI, 8.9). None of the compounds showed notable activity [...] flavonoids 1–6, 3-methoxy-4-hydroxybenzoic acid (7), and benzyltetrahydroisoquinoline alkaloids laudanine (8) and laudanosine (9) from C. gratissimus, and pinoresinol (10), isorhamnetin (11), (-)-pseudosemiglabrin
HIV infection in women: immunological markers and the influence of pregnancy (Publications)
there being no influence of pregnancy on either CD4% or CD8%. CONCLUSIONS: In asymptomatic HIV infection, changes in the absolute levels of CD4 and CD8 lymphocyte counts are primarily related to changes in [...] n and post-pregnancy changes in immunological markers: an increase in the CD4% and a decrease in CD8%. However, causality cannot be implied as pregnancy itself may be associated with considerable lifestyle [...] in the other components of the white cell count because there were no...
Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B3 and B4, and related 5,80'-coupled monomeric alkaloids, ikelacongolines A–D, from a... (Publications)
(4), and four related 5,8′-linked monomeric alkaloids, named ikelacongolines A–D (5a, 5b, 6, and 7). The dimers 3 and 4 are structurally unusual quateraryls comprising two 5,8′-coupled monomers linked [...] liana, three of them belonging to the subclass of 5,8′-coupled naphthylisoquinoline alkaloids, whereas two compounds exhibited a less frequently occurring 7,8′-biaryl linkage. The stereostructures of the new
