3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity (Publications)
hydrophobic, donor, and acceptor properties had good predictive ability with a q2=0.699, r2=0.974, SEE, standard error of estimate=0.1, and F=120.04. The results have been used as a guide to design compounds
Carbon monoxide exposures and kitchen concentrations from cookstove-related woodsmoke in San Marcos, Peru (Publications)
(95% CI) for child, mother, and kitchen measurements were 1·1 (0·9-1·2), 1·4 (1·3-1·6), and 7·3 (6·4-8·3) ppm in control households, and 1·0 (0·9-1·1), 1·4 (1·3-1·6), and 7·3 (6·4-8·2) ppm among intervention
Determination of methoxyphenols in ambient atmospheric particulate matter: tracers for wood combustion (Publications)
recovery = 63-100%; precision = 2-6%; analytical limit of detection (S/N 2) = 0.002 microg/mL; limit of quantitation = 0.07-0.45 ng/m3 (assuming a 14 m3 sample). The improved method was applied to ambient
Noise estimation model development using high-resolution transportation and land use regression (Publications)
good fits for our model, with rush hour "out of sample" ten folds cross-validated R(2) of 0.79 (Tel Aviv) and 0.52 (Beer Sheva). The Tel Aviv model performance was also tested with independent monitoring [...] monitoring data in an adjacent city (Bat Yam), presenting a good performance as well (R(2) of 0.93). The findings demonstrate the viability of using a LUR approach for applying high-resolution spatial data to
Evaluation of standard field and laboratory methods to compare protection times of the topical repellents PMD and DEET (Publications)
DEET in the AIC test were 0.5, 2 and 2 hours against Ae. aegypti, An. stephensi and Cx. quinquefasciatus, respectively, and the corresponding median CPTs for PMD were 0.5, 1 and 0.5 hours. In conclusion,
Using open street map data in environmental exposure assessment studies: Eastern Massachusetts, Bern region, and South Israel as a case study (Publications)
all regions were robust, with Massachusetts showing the best fits (R(2) 0.93). Results in Bern (R(2) 0.78) and Beer-Sheva (R(2) 0.77) were only slightly lower. We conclude by suggesting that OSM data can
Highly heterogeneous residual malaria risk in western Thailand (Publications)
vivax and 0 to 1.3% for P. falciparum. Ninety percent of infections were asymptomatic. The annual molecular force of blood-stage infection (molFOB) was estimated by microsatellite genotyping to be 0.24 new [...] new infections per person-year for P. vivax and 0.02 new infections per person-year for P. falciparum. The distribution of infections was heterogenous, that is, the vast majority of infections (> 80%) were
Changes in Healthcare Utilization During the COVID-19 Pandemic and Potential Causes-A Cohort Study From Switzerland (Publications)
to report changes [Incidence Rate Ratio (IRR) = 2.15, p = 0.002]. Those with hypertension were least likely to report changes [IRR = 0.35, p = 0.019]. Conclusion: Few of those requiring regular treatment
qRT-PCR versus IFA-based quantification of male and female gametocytes in low-density <em>Plasmodium falciparum</em> infections and their relevance... (Publications)
qRT-PCR. The mean proportion of males was 0.39 (95% confidence interval, 0.33-0.44) by pfs25/pfmget qRT-PCR; this correlated well with IFA results (Pearsons r2 = 0.91; P < .001). A Poisson model fitted to
A near-complete series of four atropisomeric jozimine A2-Type naphthylisoquinoline dimers with antiplasmodial and cytotoxic activities and related... (Publications)
fibrosarcoma (HT1080), and multiple myeloma (MM.1S) cancer cells, displaying IC50 values of 12.0, 9.0, and 5.0 muM, respectively, whereas jozibrevines A (1a) and B (1b) were nontoxic in this concentration [...] antiplasmodial activities in the submicromolar range, with 1a being the most potent compound (IC50, 0.012 muM). Furthermore, jozimine A2 (1d) showed cytotoxicity against human colon carcinoma (HT-29),
