Respiratory effects of environmental tobacco exposure are enhanced by bronchial hyperreactivity (Publications)
statistical significance only for the symptom of dyspnea (p < 0.01). Lower FEV(1)/FVC (mean +/- SD, 72.9 +/- 7.7 vs. 76.8 +/- 6.1%; p < 0.01) and FEF(25-75) (forced expiratory flow, midexpiratory phase)/FVC [...] strongly associated with the development of cough (odds ratio, 2.1; 95% confidence interval, 1.2-3.7; p = 0.01). In subjects with BHR exposed to ETS at both surveys, a trend for strong associations were observed [...] phase)/FVC (mean +/- SD, 56.1 +/- 22.5 vs. 68.1 +/- 21.6%; p < 0.01)...
Can cortical thickness asymmetry analysis contribute to detection of at-risk mental state and first-episode psychosis? A pilot study (Publications)
0006; sensitivity, 70.0%; specificity, 85.0%) and showed a trend toward helping to distinguish the ARMS group from control subjects (P = .06; sensitivity, 75.0%; specificity, 65.0%). CONCLUSION: Cortical
Years of life lost attributable to air pollution in Switzerland: dynamic exposure-response model (Publications)
Utah Valley and of the coal ban in Dublin were 0.88 and 0.11. Assuming a time constant k of 0.5 resulted in 42 400 (95% CI 22 600-63 600) YLLs, with 4.0% being ascribed to infant deaths. A total of 39%
Helminth infections and risk factor analysis among residents in Eryuan county, Yunnan province, China (Publications)
and OR=5.32, 95% CI=3.42-8.28, respectively). The opposite was found for T. trichiura (OR=0.31, 95% CI=0.14-0.70). Our findings can guide the design and spatial targeting of control interventions against [...] of Ascaris lumbricoides, Taenia spp., Trichuris trichiura and hookworms was 15.4%, 3.5%, 1.7% and 0.3%, respectively. The seroprevalence of Trichinella spp. was 58.8% and that of cysticercosis 18.5%.
Genetic similarity of hepatitis C virus and fibrosis progression in chronic and recurrent infection after liver transplantation (Publications)
significant positive relationship between HCV genetic similarity in Core (r = 0.550, P < 0.01) and NS5b regions (r = 0.847, P < 0.01) and the yearly rate of fibrosis progression in nontransplanted patients
Inhibitory activity of marine sponge-derived natural products against parasitic protozoa (Publications)
potent (IC50 0.60 mu g/mL), whereas 9 and 12 were the most active compounds against T. cruzi, with IC50 values around 4 mu g/mL. Compound 12 showed the strongest leishmanicidal activity (IC50 0.75 mu g/mL) [...] g/mL), which was comparable to that of miltefosine (IC50 0.20 mu g/mL). The best antiplasmodial effect was exerted by compound 11 (IC50 0.43 mu g/mL), followed by compounds 7, 10, and 12 with IC50 values
Severe malaria in Europe: an 8-year multi-centre observational study (Publications)
were used across 28 study centres. The risk of acute renal failure (36 vs 17% p = 0.04) or cerebral malaria (54 vs 20%, p = 0.001) was significantly higher in patients > /=60 years than in younger patients [...] ventilation was significantly associated with the risk of death in the study population (13 vs 0%, p = 0.001). Post-artemisinin delayed haemolysis was reported in 19/70 (27%) patients treated with intravenous
Long-term effect of a school-based physical activity program (KISS) on fitness and adiposity in children: a cluster-randomized controlled trial (Publications)
controls had a significantly higher average level of aerobic fitness at follow-up (0.373 z-score units [95%-CI: 0.157 to 0.59, p = 0.001] corresponding to a shift from the 50th to the 65th percentile between baseline
Modifying effect of a common polymorphism in the interleukin-6 promoter on the relationship between long-term exposure to traffic-related particulate... (Publications)
95% confidence interval -3.5 to 0.01; pinteraction(additive) = 0.028); and low frequency power (LF) (GG-carriers: -5.7%; 95%CI: -10.4 to -0.8; pinteraction(dominant) = 0.049). CONCLUSIONS: Our results are
Long-term exposure to air pollution and cardiovascular mortality: an analysis of 22 european cohorts (Publications)
approximately 1.0, except for particle mass and cerebrovascular disease mortality; for PM2.5, the hazard ratio was 1.21 (95% confidence interval = 0.87-1.69) per 5 mug/m and for PM10, 1.22 (0.91-1.63) per [...] association of air pollutants with mortality from overall CVD and with specific CVDs were approximately 1.0, with the exception of particulate mass and cerebrovascular disease mortality for which there was suggestive
