Genetic similarity of hepatitis C virus and fibrosis progression in chronic and recurrent infection after liver transplantation (Publications)
significant positive relationship between HCV genetic similarity in Core (r = 0.550, P < 0.01) and NS5b regions (r = 0.847, P < 0.01) and the yearly rate of fibrosis progression in nontransplanted patients
Inhibitory activity of marine sponge-derived natural products against parasitic protozoa (Publications)
potent (IC50 0.60 mu g/mL), whereas 9 and 12 were the most active compounds against T. cruzi, with IC50 values around 4 mu g/mL. Compound 12 showed the strongest leishmanicidal activity (IC50 0.75 mu g/mL) [...] g/mL), which was comparable to that of miltefosine (IC50 0.20 mu g/mL). The best antiplasmodial effect was exerted by compound 11 (IC50 0.43 mu g/mL), followed by compounds 7, 10, and 12 with IC50 values
Severe malaria in Europe: an 8-year multi-centre observational study (Publications)
were used across 28 study centres. The risk of acute renal failure (36 vs 17% p = 0.04) or cerebral malaria (54 vs 20%, p = 0.001) was significantly higher in patients > /=60 years than in younger patients [...] ventilation was significantly associated with the risk of death in the study population (13 vs 0%, p = 0.001). Post-artemisinin delayed haemolysis was reported in 19/70 (27%) patients treated with intravenous
Long-term effect of a school-based physical activity program (KISS) on fitness and adiposity in children: a cluster-randomized controlled trial (Publications)
controls had a significantly higher average level of aerobic fitness at follow-up (0.373 z-score units [95%-CI: 0.157 to 0.59, p = 0.001] corresponding to a shift from the 50th to the 65th percentile between baseline
Modifying effect of a common polymorphism in the interleukin-6 promoter on the relationship between long-term exposure to traffic-related particulate... (Publications)
95% confidence interval -3.5 to 0.01; pinteraction(additive) = 0.028); and low frequency power (LF) (GG-carriers: -5.7%; 95%CI: -10.4 to -0.8; pinteraction(dominant) = 0.049). CONCLUSIONS: Our results are
Long-term exposure to air pollution and cardiovascular mortality: an analysis of 22 european cohorts (Publications)
approximately 1.0, except for particle mass and cerebrovascular disease mortality; for PM2.5, the hazard ratio was 1.21 (95% confidence interval = 0.87-1.69) per 5 mug/m and for PM10, 1.22 (0.91-1.63) per [...] association of air pollutants with mortality from overall CVD and with specific CVDs were approximately 1.0, with the exception of particulate mass and cerebrovascular disease mortality for which there was suggestive
High HIV prevalence and associated risk factors among female sex workers in Rwanda (Publications)
was an inverse relationship between HIV prevalence and comprehensive HIV knowledge (aOR = 0.65, [95% CI: 0.48-0.88]). HIV prevalence was high among a sample of FSWs in Rwanda, and successful prevention [...] 1338 women included in the study, 1112 consented to HIV testing, and the overall HIV prevalence was 51.0%. Sixty percent had been engaged in sex work for less than five years and 80% were street based. In
Relative performance of indoor vector control interventions in the Ifakara and the West African experimental huts (Publications)
(induced exit), blood-feeding and mortality of mosquitoes. METHODS: Metofluthrin mosquito coils (0.00625% and 0.0097%) and Olyset(R) Net vs control nets (untreated, deliberately holed net) were evaluated against [...] while the West African huts captured a median of 8/ night (rate ratio 3.37, 95% CI: 2.30-4.94, P < 0.0001) and this difference in mosquito entry was similar for Olyset(R) Net and more pronounced for spatial [...] 4-fold higher mosquito exit relative to the West African huts (odds...
Do surveys with paper and electronic devices differ in quality and cost? Experience from the Rufiji Health and Demographic Surveillance System in... (Publications)
households for the paper records and 2% (15) for the electronic records (p < 0.001). There were differences in the types of errors (p = 0.03). Of the errors occurring, a higher proportion were due to accuracy [...] per household was 9.4 minutes (90% central range 6.4, 12.2) for paper and 8.3 (6.1, 12.0) for electronic surveys (p = 0.001). Surveys using electronic tools, compared with paper-based tools, were less costly
Long run height and education implications of early life growth faltering: a synthetic panel analysis of 425 birth cohorts in 21 low- and... (Publications)
z-score (HAZ) in childhood was - 1.53 [range: - 2.73, - 0.348]. In fully adjusted models, each unit increase in cohort childhood HAZ was associated with a 2.0 cm [95% CI: 1.09-2.9] increase in adult height, with [...] between early childhood height and adult educational attainment was found to be inconclusive (0.269, 95% CI: [- 0.68-1.22]). CONCLUSIONS: While early childhood linear growth at the cohort level appears to
