Efficacy and safety of ascending dosages of moxidectin and moxidectin-albendazole against <em>Trichuris trichiura</em> in adolescents: a randomized... (Publications)
list T. trichiura infected adolescents were randomly assigned to 7 treatment arms: 8, 16 or 24 mg moxidectin monotherapy or 8, 16, 24 mg moxidectin plus 400 mg albendazole combination therapy or placebo. The [...] of 290 adolescents were enrolled (41 or 42 per arm). CRs against T. trichiura were 43, 46, 44% for 8, 16 and 24 mg of moxidectin alone and 60, 62 and 66% for the same moxidectin dosages plus 400 mg of [...] . There is no benefit of increasing the moxidectin dose. The...
Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity (Publications)
two agents into one molecule. Compounds 5-8 possessed improved in vitro activity against a CQ-resistant strain of Plasmodium falciparum, and examples 7 and 8 were active in vivo in mouse models of malaria
Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity (Publications)
two agents into one molecule. Compounds 5-8 possessed improved in vitro activity against a CQ-resistant strain of Plasmodium falciparum, and examples 7 and 8 were active in vivo in mouse models of malaria
School-based preventive chemotherapy program for schistosomiasis and soil-transmitted helminth control in Angola: 6-year impact assessment (Publications)
prevalence for Huambo was -28.4% (95%CI -92.1, 35.2), Uige -10.7% (95%CI -30.2, 8.8), and Zaire -20.9% (95%CI -79.5, 37.8). A higher proportion of WASH-supported schools had improved water sources, and [...] 28.2%. Relative reduction in schistosomiasis prevalence from 2014 for Huambo was 18.8% (95% confidence interval (CI) 8.6, 29.0), Uige -92.3% (95%CI -162.2, -58.3), and Zaire -14.0% (95%CI -48.6, 20.6).
Dynamic assessment of right ventricular volumes and function by real-time three-dimensional echocardiography: a comparison study with magnetic... (Publications)
25.5 mL, P = .02; and 58.8 +/- 18.4 vs 64.5 +/- 24.1 mL, P < .01, respectively), while no significant difference was observed for ejection fraction (47.8 +/- 8.5% vs 48.2 +/- 10.8%, P = .57). Correlation [...] interval [CI], -31.3 to 51.7 mL) for end-diastolic volume, r = 0.83 (mean difference, 4.5 mL; 95% CI, -23.8 to 32.9 mL) for end-systolic volume, r = 0.77 (mean difference, 5.7 mL; 95% CI, -24.6 to 36.0 mL) for
School-based preventive chemotherapy program for schistosomiasis and soil-transmitted helminth control in Angola: 6-year impact assessment (Publications)
prevalence for Huambo was -28.4% (95%CI -92.1, 35.2), Uige -10.7% (95%CI -30.2, 8.8), and Zaire -20.9% (95%CI -79.5, 37.8). A higher proportion of WASH-supported schools had improved water sources, and [...] 28.2%. Relative reduction in schistosomiasis prevalence from 2014 for Huambo was 18.8% (95% confidence interval (CI) 8.6, 29.0), Uige -92.3% (95%CI -162.2, -58.3), and Zaire -14.0% (95%CI -48.6, 20.6).
Dynamic assessment of right ventricular volumes and function by real-time three-dimensional echocardiography: a comparison study with magnetic... (Publications)
25.5 mL, P = .02; and 58.8 +/- 18.4 vs 64.5 +/- 24.1 mL, P < .01, respectively), while no significant difference was observed for ejection fraction (47.8 +/- 8.5% vs 48.2 +/- 10.8%, P = .57). Correlation [...] interval [CI], -31.3 to 51.7 mL) for end-diastolic volume, r = 0.83 (mean difference, 4.5 mL; 95% CI, -23.8 to 32.9 mL) for end-systolic volume, r = 0.77 (mean difference, 5.7 mL; 95% CI, -24.6 to 36.0 mL) for
Traditional milk transformation schemes in Côte d'Ivoire and their impact on the prevalence of <em>Streptococcus bovis</em> complex bacteria in dairy... (Publications)
affecting product properties. Phenotypic and molecular analyses identified SBSEC in 27/43 (62.8%) fermented and 26/67 (38.8%) unfermented milk samples. Stratified by collection stage, fermented milk at producer [...] vendor levels featured highest SBSEC prevalence of 71.4% and 63.6%, respectively. Sii with 62.8% and 38.8% as well as Streptococcus gallolyticus subsp. macedonicus with 7.0% and 7.5% were the predominant
Insufficient stability of clavulanic acid in widely used child-appropriate formulations (Publications)
In suspensions, CLA degraded to a maximum of 12.9% (95% CI -55.7%, +29.9%) at 8 degrees C and 72.3% (95% CI -82.8%, -61.8%) at a 28 degrees C ambient temperature during an observation period of 7 days [...] s and dispersible tablets commercially available in Switzerland at different ambient temperatures (8 degrees C vs. 28 degrees C over 7 days, and 23 degrees C vs. 28 degrees C over 24 h, respectively).
HIV-1-specific CD4(+) responses in primary HIV-1 infection predict disease progression (Publications)
survival advantage imposed by CD8(+) T-cell immunity (P = 0.82). CONCLUSION: These data support a dominant protective role for CD4(+) T-cell immunity in PHI compared with CD8(+) T-cell responses, and are [...] SPARTAC trial were sampled at enrolment, prior to commencing any therapy. HIV-1-specific CD4(+) and CD8(+) ELISpot responses were measured by gamma interferon ELISPOT. Immunological data were associated with [...] extent lower plasma HIV RNA (P = 0.07). There was no correlation between the...
