Natural polymorphisms in <em>Mycobacterium tuberculosis </em>conferring resistance to delamanid in drug-naïve patients (Publications)
Mycobacterium tuberculosis (Mtb) complex can lead to delamanid resistance. We searched for such mutations among 129 Mtb strains from Asia, South-America, and Africa using whole-genome sequencing; 70 (54%) strains
The long road to schistosomiasis elimination in Zanzibar: a systematic review covering 100 years of research, interventions and control milestones (Publications)
Zanzibar is among the few places in sub-Saharan Africa where interruption of Schistosoma transmission seems an achievable goal. Our systematic review identifies and discusses milestones in schistosomiasis [...] between May 1928 and August 2022. The content of records was summarised to highlight the pivotal work leading towards urogenital schistosomiasis elimination and remaining research gaps. The greatest achievement
Natural polymorphisms in <em>Mycobacterium tuberculosis </em>conferring resistance to delamanid in drug-naïve patients (Publications)
Mycobacterium tuberculosis (Mtb) complex can lead to delamanid resistance. We searched for such mutations among 129 Mtb strains from Asia, South-America, and Africa using whole-genome sequencing; 70 (54%) strains
Loss of genomic diversity in a <em>Neisseria meningitidis</em> clone through a colonization bottleneck (Publications)
is the leading cause of epidemic meningitis in the 'meningitis belt' of Africa, where clonal waves of colonization and disease are observed. Point mutations and horizontal gene exchange lead to constant
Loss of genomic diversity in a <em>Neisseria meningitidis</em> clone through a colonization bottleneck (Publications)
is the leading cause of epidemic meningitis in the 'meningitis belt' of Africa, where clonal waves of colonization and disease are observed. Point mutations and horizontal gene exchange lead to constant
and Care Cascade in Women Living with HIV Cervical cancer is the leading cause ofcancer related deaths among women in sub-Saharan Africa. Women living with the human immunodeficiency virus (HIV) are six [...] women living with HIV in sub-Saharan Africa. Read more South African Cervical Cancer Screening Cohort Screening for cervical pre-cancer is available in South Africa, but there is no systematic approach [...] from the National Cancer Registry (NCR) in South Africa to assess the provision of...
Malaria: burden of disease (Publications)
and Ross confirmed that they were transmitted by female anopheline mosquitoes, malaria remains a leading cause of morbidity and mortality worldwide. Although the areas where transmission takes place have [...] chloroquine and the weak health infrastructure in many of the endemic countries, particularly in Africa, the malaria situation worsened worldwide. The last decade of the 20th century was witness to the [...] develop candidate vaccines, together with new financial support constitute...
<em>In vitro</em>, <em>ex vivo</em> and<em> in vivo</em> activity of diamidines against <em>Trypanosoma congolense</em> and <em>Trypanosoma vivax</em> (Publications)
tsetse-transmitted protozoans, Trypanosoma congolense and T. vivax, leading to huge agricultural losses throughout sub-Saharan Africa. Three drugs are available to treat Nagana in cattle (diminazene diaceturate [...] mice, respectively. This study identified a selection of diamidines, which could be considered as leads against Nagana.
Malaria: burden of disease (Publications)
and Ross confirmed that they were transmitted by female anopheline mosquitoes, malaria remains a leading cause of morbidity and mortality worldwide. Although the areas where transmission takes place have [...] chloroquine and the weak health infrastructure in many of the endemic countries, particularly in Africa, the malaria situation worsened worldwide. The last decade of the 20th century was witness to the [...] develop candidate vaccines, together with new financial support constitute...
<em>In vitro</em>, <em>ex vivo</em> and<em> in vivo</em> activity of diamidines against <em>Trypanosoma congolense</em> and <em>Trypanosoma vivax</em> (Publications)
tsetse-transmitted protozoans, Trypanosoma congolense and T. vivax, leading to huge agricultural losses throughout sub-Saharan Africa. Three drugs are available to treat Nagana in cattle (diminazene diaceturate [...] mice, respectively. This study identified a selection of diamidines, which could be considered as leads against Nagana.
