Associations of peak shifts in age-prevalence for human malarias with bednet coverage (Publications)
(C = 100%) years for Plasmodium falciparum, from 3.4 to 4.9 years for P. vivax and from 11.0 to 16.8 years for P. malariae. In small areas with no bednets the age distribution of P. falciparum parasitaemia
Inhibition of <em>Plasmodium falciparum</em> fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids (Publications)
microM), the more complex flavonoids (12-16) exhibited strong activity toward all three enzymes (IC50 0.5-8 microM). Isoflavonoids 26-28 showed moderate (IC50 7-30 microM) but selective activity against FabZ
Genomic distribution and functional characterisation of two distinct and conserved <em>Plasmodium falciparum</em> var gene 5' flanking sequences (Publications)
Members of the var gene family are located in chromosome- internal positions on chromosomes 4, 7, 8 and 12, and in subtelomeric regions of all chromosomes. Here we show that there are two distinct and
Severe dengue virus infection in travelers: risk factors and laboratory indicators (Publications)
Serological analysis revealed a secondary immune response in 17%. Spontaneous bleeding was observed in 17 (8%) patients and was associated with increased serum alanine and aspartate aminotransferase levels and
PM10 source apportionment in a Swiss Alpine valley impacted by highway traffic (Publications)
traffic-related: traffic exhaust, road dust, tire and brake wear, and road salt contributing 16 %, 8 %, 1 %, and 2 % to annual PM10 concentrations, respectively. They showed a clear dependence with distance
Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives (Publications)
analogue 49 (IC50 = 1.4 ?M) and two other compounds were more effective than pentamidine (IC50 = 1.8 ?M) against L. donovani. A prodrug, 3',4-bis(N?-methoxy)amidino-2-bromo derivative 38, was the most
High throughput multiplex assay for species identification of Papua New Guinea malaria vectors: members of the <em>Anopheles punctulatus</em>... (Publications)
Anopheles punctulatus sibling species including An. punctulatus, An. koliensis, the An. farauti complex 1-8 (includes An. hinesorum [An. farauti 2], An. torresiensis [An. farauti 3]). Distinguishing these species
Prediction of MS disability by multimodal evoked potentials: investigation during relapse or in the relapse-free interval? (Publications)
RESULTS: Median EDSST0 was 3.0 for Group 1 and 1.5 for Group 2. Mean disease durations were 2.0 and 2.8years, respectively. Median EDSST2 was 2.0 for both groups. The s-EP-QT0 significantly predicted EDSST2
Assessment of dual life stage antiplasmodial activity of British seaweeds (Publications)
exerted by U. lactuca and red seaweeds Ceramium virgatum and Halopitys incurvus (IC50 values 14.9 to 28.8 mug/mL). The LS-active extracts inhibited one or more key enzymes of the malarial type-II fatty acid
Subtle to severe hepatobiliary morbidity in <em>Opisthorchis viverrini </em>endemic settings in Southern Laos (Publications)
4%), gall wall thickening (1.2%), bile duct dilatation (1.6%), fatty liver (12.0%), kidney stones (8.6%) and cysts (7.9%) were diagnosed in considerable frequencies. In five patients (1.2%) hepatobiliary
