Golgi phosphoprotein 2 (GOLPH2) expression in liver tumors and its value as a serum marker in hepatocellular carcinomas (Publications)
a higher tumor grade (P = 0.01). A total of 97/114 (85%) BDCs showed a strong GOLPH2 expression which proved to be an independent prognostic factor for overall survival (P < 0.05). Serum levels of GOLPH2 [...] elevated in patients with HCC with underlying HCV infection (median 18 mg/L, P < 0.05) and patients with BDC (median = 14.5 mg/L, P < 0.01) in comparison to healthy controls (median 4 mg/L). Conclusion: GOLPH2
Intermittent treatment for malaria and anaemia control at time of routine vaccinations in Tanzania infants: a randomised, placebo-controlled trial (Publications)
person-year at risk) was 0.15 in the sulphadoxine-pyrimethamine group versus 0.36 in the placebo group (protective efficacy 59% [95% CI 41-72]), and the rate of severe anaemia was 0.06 in the sulphadoxin [...] e-pyrimethamine group versus 0.11 in the placebo group (50% [8-73]). Serological responses to EPI vaccines were not affected by the intervention. INTERPRETATION: This new approach to malaria control reduced
Association between long-term exposure to traffic-related air pollution and subclinical atherosclerosis: the REGICOR study (Publications)
(7,200,000 vehicle-m/day) were associated with differences of 0.56% (95% CI: -1.5, 2.6%), 2.32% (95% CI: 0.48, 4.17%), and 1.91% (95% CI: -0.24, 4.06) percent difference in IMT, respectively. Exposures [...] Exposures were positively associated with an ABI of > 1.3, but not an ABI of < 0.9. Stronger associations were observed among those with a high level of education and in men ? 60 years of age.Conclusions: Long-term
Spatio-temporal distribution of <em>Mycobacterium tuberculosis</em> complex strains in Ghana (Publications)
Ghana (1.9% of 212) than Southern Ghana (0.5% of 2339) (p = 0.020). Using the purely spatial and space-time analysis, seven significant MTBC lineage clusters (p < 0.05) were identified. Notable among the [...] and spatial display, respectively. RESULTS: Among 2,551 isolates, 2,019 (79.1%), 516 (20.2%) and 16 (0.6%) were identified as M. tuberculosis sensu stricto (MTBss), M. africanum (Maf), 15 M. bovis and 1
Assessing stool quantities generated by three specific Kato-Katz thick smear templates employed in different settings (Publications)
Mushy stool resulted in considerably lower average weights when the Vestergaard Frandsen (37.0 mg; 95 % CI: 34.9-39.0 mg) or new China CDC templates (37.4 mg; 95 % CI: 35.9-38.9 mg) were used, compared to the [...] with stool and slides plus stool after careful removal of the template were weighed to the nearest 0.1 mg. The average amount of stool that was generated on the slide was calculated for each template, [...] RESULTS: The average amount of stool generated on slides was 40.7 mg (95 %...
Prevalence of atopy and respiratory allergic diseases in the elderly SAPALDIA population (Publications)
1% in women, respectively (both p < 0.001). Prevalence rates of self-reported allergic rhinitis in subjects > 60 years old were 13.0% for men and 15.4% for women (p = 0.12), and for doctor's diagnosed asthma [...] asthma 6.6% versus 7.6%, respectively (p = 0.40). Both rhinitis and asthma prevalences were higher in persons
The contribution of malaria control interventions on spatio-temporal changes of parasitaemia risk in Uganda during 2009-2014 (Publications)
living in urban areas were associated with parasitaemia odds reduction of 46% (95% BCI: 0.51-0.57) and 57% (95% BCI: 0.40-0.53), respectively. The probability of parasitaemia risk decline in the country was
Kankanet: an artificial neural network-based object detection smartphone application and mobile microscope as a point-of-care diagnostic aid for... (Publications)
sensitivity (82.9%) and specificity (97.1%) in A. lumbricoides to standard KK interpretation (97.0% sensitivity, 96.0% specificity). The UVC could not accurately image T. trichiura or hookworm. Though Kankanet [...] respectively). Kankanet showed high sensitivity for T. trichiura in microscope images (100.0%), but low in UVC images (50.0%). CONCLUSIONS/SIGNIFICANCE: The UVC achieved comparable sensitivity to standard microscopy
Subjective burden of government-imposed Covid-19 restrictions in Switzerland: evidence from the 2022 LINK Covid-19 survey (Publications)
valued life under severe restrictions at 39% of their usual life (estimated relative utility 0.39 [0.37, 0.42]). Willingness to pay for avoiding restrictions was lowest for masks (CHF 663 [319, 1007])
Predictors of spontaneous remission and recovery among women with untreated perinatal depression in India and Pakistan (Publications)
aOR = 2.04, 95% CI 1.02–4.11), lower Patient Health Questionnaire-9 score at baseline (aOR = 0.43, 95% CI 0.20–0.90 for score of ≥20 vs. 10–14) and better social support at baseline (aOR = 2.37, 95% CI 1
