Subtle to severe hepatobiliary morbidity in <em>Opisthorchis viverrini </em>endemic settings in Southern Laos (Publications)
abdominal US. Mild, moderate and markedly advanced periductal fibrosis was diagnosed in 7.0%, 66.5%, and 17.0% of patients, respectively. Normal liver parenchyma was seen in only 9.5% of patients. Presence [...] stones (13.2%), sludge (1.4%), gall wall thickening (1.2%), bile duct dilatation (1.6%), fatty liver (12.0%), kidney stones (8.6%) and cysts (7.9%) were diagnosed in considerable frequencies. In five patients
Estimating malaria transmission intensity from <em>Plasmodium falciparum</em> serological data using antibody density models (Publications)
estimates obtained and the estimated SCR obtained from a catalytic model (r = 0.95) and with two derived measures of EIR (r = 0.74 and r = 0.81). Estimates of exposure rate obtained with the density model were
Evaluation of portable microscopic devices for the diagnosis of Schistosoma and soil-transmitted helminth infection (Publications)
7%, 91.0% and 93.0%, respectively. For S. mansoni and T. trichiura, we found sensitivities for the mobile phone microscope of 68.2% and 30.8%, respectively, and specificities of 64.3% and 71.0%, respectively
Approved oncology drugs lack <em>in vivo</em> activity against <em>Trichuris muris</em> despite <em>in vitro</em> activity (Publications)
1.8 and 5.0 muM. Except for tamoxifen citrate, all in vitro active drugs were protein kinase inhibitors. None of the drugs tested in vivo showed efficacy, revealing worm burden reductions of 0-24 % and [...] and worm expulsion rates of 0-7.9 %. The promising in vitro activities of protein kinases could not be confirmed in vivo. Drug discovery against STH should be strengthened including the definition of compound
2-Octadecynoic acid as a dual life stage inhibitor of <em>Plasmodium</em> infections and plasmodial FAS-II enzymes (Publications)
falciparum FAS-II (PfFAS-II) elongation enzymes PfFabI, PfFabZ, and PfFabG with the lowest IC50 values (0.28-0.80µg/ml, respectively). Molecular modeling studies provided insights into the molecular aspects [...] identified as the best inhibitor of Plasmodium berghei parasites with ten times higher potency (IC50=0.34µg/ml) than the control drug. In target determination studies, the same compound inhibited three
IgE levels, atopy markers and hay fever in relation to age, sex and smoking status in a normal adult Swiss population (Publications)
a positive Phadiatop and skin test, or being atopic were found to decrease on average by 23.0, 21.1 and 21.0%, respectively, with every 10-year increase in age. With respect to smoking status, the odds [...] of (self-reported) hay fever was highest in nonsmokers, intermediate in former smokers (odds ratio = 0.81, p
Land use regression models for ultrafine particles in six European areas (Publications)
of predictions within areas was high (ICC 0.73-0.98). External validation R2 was 53% in Basel and 50% in The Netherlands. Combined area models were robust (ICC 0.93-1.00) and explained UFP variation almost
Land use regression modeling of outdoor noise exposure in informal settlements in Western Cape, South Africa (Publications)
during day (6:00-18:00) was 60.0 A-weighted decibels (dB(A)) (interquartile range 56.9-62.9 dB(A)), during night (22:00-6:00) 52.9 dB(A) (49.3-55.8 dB(A)) and average Lden was 63.0 dB(A) (60.1-66.5 dB(A)). Main [...] model were related to road traffic and household density. Model performance was low (adjusted R2 = 0.130) suggesting that other influences than those represented in the geographic predictors are relevant
Comparison of antigen and antibody responses in repeat lymphatic filariasis transmission assessment surveys in American Samoa (Publications)
responses to Wb123, Bm14, and Bm33 was 1.0%, 6.8% and 12.0%, respectively. In 2015, overall prevalence of positive Bm14 and Bm33 responses declined significantly to 3.0% (p
Measuring early childhood development in Brazil: validation of the Caregiver Reported Early Development Instruments (CREDI) (Publications)
alpha suggested adequate internal consistency/inter-item reliability (alpha> 0.80) for the CREDI within each of the six age groups (0-5, 6-11, 12-17, 18-23, 24-29 and 30-35 months of age). Multivariate analyses [...] Development Indicators; PRIDI). The full sample includes 1,265 Brazilian caregivers of children from 0 to 35 months (678 of which comprising an in-person sample and 587 an online sample). RESULTS: Results
