RTS,S malaria vaccine pilot studies: addressing the human realities in large-scale clinical trials (Publications)
malaria control and elimination efforts will have a major impact on public health in sub-Sahara Africa. The first malaria vaccine, RTS,S, now enters pilot implementation in three African countries. These [...] strategies that address the human realities in large-scale clinical trials and pilot implementation, leading to positive public health outcomes.
<em>In vitro</em> screening of traditional South African malaria remedies against <em>Trypanosoma brucei rhodesiense</em>, <em>Trypanosoma cruzi,... (Publications)
Three hundred extracts were prepared from plants traditionally used in South Africa to treat malaria and screened IN VITRO for activity against TRYPANOSOMA BRUCEI RHODESIENSE, TRYPANOSOMA CRUZI, LEISHMANIA [...] This screening is the starting point for a HPLC-based activity profiling project in antiprotozoal lead discovery
RTS,S malaria vaccine pilot studies: addressing the human realities in large-scale clinical trials (Publications)
malaria control and elimination efforts will have a major impact on public health in sub-Sahara Africa. The first malaria vaccine, RTS,S, now enters pilot implementation in three African countries. These [...] strategies that address the human realities in large-scale clinical trials and pilot implementation, leading to positive public health outcomes.
of the State Secretariat for Education, Research and Innovation (SERI) with Swiss TPH as the leading house and the Ivorian government (Ministry of Higher Education and Scientific Research). Around 160
The genome of <em>Mycobacterium africanum</em> west African 2 reveals a lineage-specific locus and genome erosion common to the <em>M.... (Publications)
an ancient lineage of the M. tuberculosis complex that commonly causes human tuberculosis in West Africa and has an attenuated phenotype relative to M. tuberculosis. METHODOLOGY/PRINCIPAL FINDINGS: In search [...] of two important lineages within the complex: the "modern" M. tuberculosis group and the lineage leading to M. bovis. Closely related to M. bovis and other animal strains within the M. tuberculosis complex [...] for the next generation of diagnostics and vaccines, in order to ensure...
The genome of <em>Mycobacterium africanum</em> west African 2 reveals a lineage-specific locus and genome erosion common to the <em>M.... (Publications)
an ancient lineage of the M. tuberculosis complex that commonly causes human tuberculosis in West Africa and has an attenuated phenotype relative to M. tuberculosis. METHODOLOGY/PRINCIPAL FINDINGS: In search [...] of two important lineages within the complex: the "modern" M. tuberculosis group and the lineage leading to M. bovis. Closely related to M. bovis and other animal strains within the M. tuberculosis complex [...] for the next generation of diagnostics and vaccines, in order to ensure...
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188... (Publications)
sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21·1% in 1990 to 31·2% in 2013. INTERPRETATION: Ageing of the world's population is leading to a [...] tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates [...] rate decreased little from 114·87 per 1000 people to 110·31 per 1000...
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188... (Publications)
sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21·1% in 1990 to 31·2% in 2013. INTERPRETATION: Ageing of the world's population is leading to a [...] tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates [...] rate decreased little from 114·87 per 1000 people to 110·31 per 1000...
<em>Mycobacterium ulcerans</em> disease (Buruli ulcer) (Publications)
Buruli ulcer is an infection of the subcutaneous tissue leading to chronic necrotizing skin ulcers. Sub-Saharan Africa carries the main burden of BU, but it also occurs in the Americas and the Western
Discovery of an orally active nitrothiophene-based antitrypanosomal agent (Publications)
caused by Trypanosoma brucei gambiense and rhodesiense, is a parasitic disease endemic to sub-Saharan Africa. Untreated cases of HAT can be severely debilitating and fatal. Although the number of reported cases [...] mouse models. Based on its excellent bioavailability, compound 10 and its analogs are candidates for lead optimization and pre-clinical investigations.
