A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order (Publications)
phenotypes (rs2155219; P(grass) = 9.4 x 10(-9); P(AR) = 3.8 x 10(-8)). The third genome-wide significant variant was rs17513503 (P(grass) = 1.2 x 10(-8); PAR = 7.4 x 10(-7)) which was located near transmembrane [...] polymorphisms were investigated in 4 large European adult cohorts for AR (3,933 self-reported cases vs 8,965 control subjects) and grass sensitization (2,315 cases vs 10,032 control subjects). RESULTS: Three [...] was strongly associated with grass sensitization and weakly with AR...
Seroprevalence and risk factors for Q fever and Rift Valley fever in pastoralists and their livestock in Afar, Ethiopia: a One Health approach (Publications)
3) in livestock overall; with 51.9% in goats (95%CI 44.9-58.8), 39.9% in sheep (95%CI 24.6-51.2), 16.3% in camels (95%CI 10.4-24.6) and 8.8% in cattle (95%CI 5.0-15.0). For Rift Valley fever the seroprevalence [...] overall; cattle had the highest seroprevalence (8.3%, 95%CI 3.3-19.2), followed by goats (2.7%; 95%CI 1.4-5.1), sheep (2.5%; 95%CI 1.0-5.9) and camels (1.8%; 95%CI 0.4-6.9). Human Q fever seropositivity
Seroprevalence and risk factors for Q fever and Rift Valley fever in pastoralists and their livestock in Afar, Ethiopia: a One Health approach (Publications)
3) in livestock overall; with 51.9% in goats (95%CI 44.9-58.8), 39.9% in sheep (95%CI 24.6-51.2), 16.3% in camels (95%CI 10.4-24.6) and 8.8% in cattle (95%CI 5.0-15.0). For Rift Valley fever the seroprevalence [...] overall; cattle had the highest seroprevalence (8.3%, 95%CI 3.3-19.2), followed by goats (2.7%; 95%CI 1.4-5.1), sheep (2.5%; 95%CI 1.0-5.9) and camels (1.8%; 95%CI 0.4-6.9). Human Q fever seropositivity
Air pollution in Switzerland: quantification of health effects using epidemiologic data (Publications)
(+25% +8.4/increase in long-term prevalence by 3,513 +/-1.475); bronchitis among children (35% +/-13/5,180 +/-2,590 additional children sufferers in a year); repeated cough among children (+54% +/-8.8/23,490 [...] 490 +/-5,873 additional children per year); cough/phlegm in adults (+12.8% +/-7.8/1.56 +/-1.08 million person-days per year); hospital admissions for respiratory diseases (+1.47% +/-0.5/71 +/-24 additional
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order (Publications)
phenotypes (rs2155219; P(grass) = 9.4 x 10(-9); P(AR) = 3.8 x 10(-8)). The third genome-wide significant variant was rs17513503 (P(grass) = 1.2 x 10(-8); PAR = 7.4 x 10(-7)) which was located near transmembrane [...] polymorphisms were investigated in 4 large European adult cohorts for AR (3,933 self-reported cases vs 8,965 control subjects) and grass sensitization (2,315 cases vs 10,032 control subjects). RESULTS: Three [...] was strongly associated with grass sensitization and weakly with AR...
Prevalence of airflow obstruction in smokers and never smokers in Switzerland (Publications)
AO ranged from 2.5% in subjects aged 30-39 to 8.0% in those aged 70 or more. In multivariate analysis, age (ORaged70+ vs aged 30-39 2.8), smoking (OR 1.8) and asthma, (OR 6.7) were associated with AO.
Antiplasmodial ealapasamines A-C,'mixed' naphthylisoquinoline dimers from the Central African liana <em>Ancistrocladus ealaensis</em> (Publications)
unsymmetric dimers are the first stereochemically fully assigned cross-coupling products of a 5,8'- and a 7,8'-coupled naphthylisoquinoline linked via C-6' in both naphthalene portions. So far, only two other [...] dimers with a central 6,6''-axis, yet, in contrast to the ealapasamines, usually consisting of two 5,8'-coupled monomers, like e.g., in michellamine B. The new dimers 1-3 contain six elements of chirality
Prevalence of airflow obstruction in smokers and never smokers in Switzerland (Publications)
AO ranged from 2.5% in subjects aged 30-39 to 8.0% in those aged 70 or more. In multivariate analysis, age (ORaged70+ vs aged 30-39 2.8), smoking (OR 1.8) and asthma, (OR 6.7) were associated with AO.
Antiplasmodial ealapasamines A-C,'mixed' naphthylisoquinoline dimers from the Central African liana <em>Ancistrocladus ealaensis</em> (Publications)
unsymmetric dimers are the first stereochemically fully assigned cross-coupling products of a 5,8'- and a 7,8'-coupled naphthylisoquinoline linked via C-6' in both naphthalene portions. So far, only two other [...] dimers with a central 6,6''-axis, yet, in contrast to the ealapasamines, usually consisting of two 5,8'-coupled monomers, like e.g., in michellamine B. The new dimers 1-3 contain six elements of chirality
Efficacy and safety of moxidectin-albendazole and ivermectin-albendazole combination therapy compared to albendazole monotherapy in adolescents and... (Publications)
the CR of 13.4% (9/67) in the albendazole arm (differences: 1.8%-points [95% confidence interval: -10.1 to 13.6]; 9.1%-points [-3.9 to 21.8], respectively). Most common adverse events were abdominal pain [...] clinically eligible participants were randomly assigned (1:1:1) to receive single oral doses of moxidectin (8 mg) and albendazole (400 mg), ivermectin (200 microg/kg) and albendazole (400 mg), or albendazole (400 [...] pain (range across arms: 11.9-20.9%), headache (4.7-14.3%), and itching...
