<em>Mycobacterium ulcerans</em> mouse model refinement for pre-clinical profiling of vaccine candidates (Publications)
Buruli Ulcer is a neglected tropical disease leading to extensive disabilities and morbidity in West Africa. In this paper we sought to characterize various strains of Mycobacterium ulcerans (M.ulcerans)
Mycobacterium ulcerans disease (Buruli ulcer) (Publications)
Buruli ulcer is an infection of the subcutaneous tissue leading to chronic necrotizing skin ulcers. Sub-Saharan Africa carries the main burden of BU, but it also occurs in the Americas and the Western
Discovery of an orally active nitrothiophene-based antitrypanosomal agent (Publications)
caused by Trypanosoma brucei gambiense and rhodesiense, is a parasitic disease endemic to sub-Saharan Africa. Untreated cases of HAT can be severely debilitating and fatal. Although the number of reported cases [...] mouse models. Based on its excellent bioavailability, compound 10 and its analogs are candidates for lead optimization and pre-clinical investigations.
<em>Mycobacterium ulcerans</em> mouse model refinement for pre-clinical profiling of vaccine candidates (Publications)
Buruli Ulcer is a neglected tropical disease leading to extensive disabilities and morbidity in West Africa. In this paper we sought to characterize various strains of Mycobacterium ulcerans (M.ulcerans)
Epidemiology of <em>Schistosoma mansoni</em> infection in Ituri Province, north-eastern Democratic Republic of the Congo (Publications)
Schistosomiasis, caused by Schistosoma mansoni, is of great significance to public health in sub-Saharan Africa. In the Democratic Republic of Congo (DRC), information on the burden of S. mansoni infection is [...] between 10 and 29 years. Preschool children were highly infected (62.3%). Key risk factors were poor housing structure (odds ratio [OR] 2.1, 95% 95% confidence interval [CI] 1.02-4.35), close proximity to water
Epidemiology of <em>Schistosoma mansoni</em> infection in Ituri Province, north-eastern Democratic Republic of the Congo (Publications)
Schistosomiasis, caused by Schistosoma mansoni, is of great significance to public health in sub-Saharan Africa. In the Democratic Republic of Congo (DRC), information on the burden of S. mansoni infection is [...] between 10 and 29 years. Preschool children were highly infected (62.3%). Key risk factors were poor housing structure (odds ratio [OR] 2.1, 95% 95% confidence interval [CI] 1.02-4.35), close proximity to water
Oesophageal varices, schistosomiasis, and mortality among patients admitted with haematemesis in Mwanza, Tanzania: a prospective cohort study (Publications)
sociodemographics and geography. Retrospective studies of endoscopies in much of Africa have documented oesophageal varices as a leading cause of UGIB. Prospective studies describing outcomes and associations with [...] ic regions. These interventions have potential to reduce UGIB-related morbidity and mortality in Africa
Oesophageal varices, schistosomiasis, and mortality among patients admitted with haematemesis in Mwanza, Tanzania: a prospective cohort study (Publications)
sociodemographics and geography. Retrospective studies of endoscopies in much of Africa have documented oesophageal varices as a leading cause of UGIB. Prospective studies describing outcomes and associations with [...] ic regions. These interventions have potential to reduce UGIB-related morbidity and mortality in Africa
include the diagnosis, epidemiology and integrated control of helminth infections in sub-Saharan Africa. Recently, Knopp was appointed as an Assistant Professor (without tenure track) at the University [...] recognition of the important research we are doing to mitigate the impact of NTDs in Sub-Saharan Africa.” Said Stefanie Knopp, Group Leader at Swiss TPH. Novel tools and strategies for breaking schistosomiasis [...] possible” said Jürg Utzinger, Director of Swiss TPH. Helminth Interventions...
can acquire new expertise thanks to our partners in Siberia." Leading institution in helminth drug development Swiss TPH is one of the leading institutions worldwide in discovering novel treatments and [...] Although many patients do not show symptoms, chronic infection of opisthorchiasis can eventually lead to an infection of the gall bladder, obstructive jaundice, an enlarged liver and/or malignant cancer [...] tested in the global north. "This is a very different setting from what we are...
