Molecular genotyping in a malaria treatment trial in Uganda - unexpected high rate of new infections within 2 weeks after treatment (Publications)
recurrent samples were successfully analysed and were resolved as 79 recrudescences (1AS = 32, 3AS = 8, SP = 39) and 77 as new infections (1AS = 29, 3AS = 27, SP = 21). The ratios of proportions of new to
Indoors man-biting mosquitoes and their implication on malaria transmission in Mpwapwa and Iringa Districts, Tanzania (Publications)
5:1, respectively. Indoor pyrethrum spray catch gave an overall estimate of An. gambiae density of 8 and 0.6 mosquitoes per room in Iringa and Mpwapwa, respectively, whereas light trap collections gave
Tuberculosis in pediatric antiretroviral therapy programs in low- and middle-income countries: diagnosis and screening practices (Publications)
in 38 (26%), gastric aspirate microscopy in 35 (24%), culture in 25 (17%), and Xpert MTB/RIF in 11 (8%) children. CONCLUSIONS: Induced sputum and Xpert MTB/RIF were infrequently available to diagnose childhood
Long-term associations of outdoor air pollution with mortality in Great Britain (Publications)
microg/m(3) BS and 13.2% (95% CI 11.5% to 14.9%) per 10 ppb SO(2), and in the most recent period (1994-8) it was 19.3% (95% CI 5.1% to 35.7%) and 21.7% (95% CI 2.9% to 38.5%), respectively. CONCLUSIONS: These
Severe malaria and concomitant bacteraemia in children admitted to a rural Mozambican hospital (Publications)
was an independent risk factor for death among severe malaria patients (adjusted OR 6.2, 95% CI 2.8-13.7, P = 0.0001). Streptococcus pneumoniae, Gram-negative bacteria, Staphilococcus aureus and non-typhoid
Metabolic profiling of an<em> Echinostoma caproni</em> infection in the mouse for biomarker discovery (Publications)
concentrations of urinary creatine. The main changes in the urine metabolic profile started at day 8 post-infection, characterized by increased relative concentrations of trimethylamine and phenylacetylglycine
Interaction between asthma and smoking increases the risk of adult airway obstruction (Publications)
association among current smokers (OR 25.6, 95% CI 15.6-41.9) than among never-smokers (OR 11.2, 95% CI 6.8-18.6) (RERI 12.02, 95% CI 1.96-22.07). Stratifying by atopy, the association between smoking and asthma
Low coverage of central point vaccination against dog rabies in Bamako, Mali (Publications)
population of Commune 1 was 3459 dogs (95% CI: 2786-4131) and the proportion of ownerless dogs was about 8%. The low coverage observed is primarily attributed to low participation by dog owners. Dog owners reported
Benzo[b]quinolizinium derivatives have a strong antimalarial activity and inhibit indoleamine dioxygenase (Publications)
logy. In this study, we screened a natural compound library against mouse IDO-1 and identified the 8-aminobenzo[b]quinolizinium 2C: as inhibitor of IDO-1 with nanomolar potency (IC50 164 nM). Twenty-one
The activities of current antimalarial drugs on the life cycle stages of <em>Plasmodium</em>: a comparative study with human and rodent parasites (Publications)
formation and impact sporogony; lumefantrine impairs development in the vector; and NPC-1161B, a new 8-aminoquinoline, inhibits sporogony. CONCLUSIONS: These data enable objective comparisons of the strengths
