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1. Advances with the Chinese anthelminthic drug tribendimidine in clinical trials and laboratory investigations (Publications)

   Advances with the Chinese anthelminthic drug tribendimidine in clinical trials and laboratory investigations

   Relevance:

   children) showed high cure rates against Ascaris lumbricoides (90.1-95.0%) and moderate-to-high cure rates against hookworm (82.0-88.4%). Another trial done in school-aged children using a rigorous diagnostic [...] tapeworm Taenia spp. and the threadworm Strongyloides stercoralis with respective cure rates of 70.0%, 40.0%, 53.3% and 36.4%. Pharmacokinetic studies in healthy Chinese volunteers indicated that after oral

2. Comparison of sensitivity and faecal egg counts of mini-FLOTAC using fixed stool samples and Kato-Katz technique for the diagnosis of <em>Schistosoma... (Publications)

   Comparison of sensitivity and faecal egg counts of mini-FLOTAC using fixed stool samples and Kato-Katz technique for the diagnosis of <em>Schistosoma mansoni</em> and soil-transmitted helminths

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   mansoni, 37.2% (95% BCI: 17.2-60.6%) for hookworm and 67.7% (95% BCI: 33.0-93.0%) for T. trichiura. The specificity ranged from 80.1-95.0% in all Mini-FLOTAC tests. Of note, Mini-FLOTAC revealed higher arithmetic [...] Mini-FLOTAC using FS2 was 50.1% (95% Bayesian credible interval (BCI): 30.9-70.2%) for hookworm and 68.0% (95% BCI: 34.9-93.5%) for T. trichiura. When applying Mini-FLOTAC using FS7, the sensitivity was 89

3. Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a... (Publications)

   Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study

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   each SD decrease in baseline CC16 concentration, p=0·0014) and ECRHS-Sp (2·4 mL/year, p=0·023); the effect in SAPALDIA was marginal (4·5 mL/year, p=0·052). Low CC16 concentration at baseline was also [...] of CC16 concentrations was associated with a subsequent FEV1 deficit of 68 mL up to age 16 years (p=0·0001), which was confirmed in children who had never smoked by age 16 years (-71 mL, p

4. Prevalence and seasonal transmission of <em>Schistosoma haematobium</em> infection among school-aged children in Kaedi town, southern Mauritania (Publications)

   Prevalence and seasonal transmission of <em>Schistosoma haematobium</em> infection among school-aged children in Kaedi town, southern Mauritania

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   CI: 1.13-2.80), being at primary school (aOR 1.73, 95% CI: 1.04-2.87) and dry season (aOR 0.56, 95% CI: 0.35-0.89) were significantly associated with S. haematobium. Among 284 potential intermediate host [...] local population were recorded by direct observation. RESULTS: The prevalence of S. haematobium was 4.0% (86/2162, 95% confidence interval (CI): 3.2-4.9%) with a geometric mean egg count per 10 ml of urine

5. Pregnancy-related morbidity and risk factors for fatal foetal outcomes in the Taabo health and demographic surveillance system, Côte d'Ivoire (Publications)

   Pregnancy-related morbidity and risk factors for fatal foetal outcomes in the Taabo health and demographic surveillance system, Côte d'Ivoire

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   who paid for delivery were at a significantly lower odds of a fatal foetal outcome (aOR = 0.39; 95% CI 0.25-0.74). CONCLUSIONS: We identified risk factors for fatal foetal outcomes in a mainly rural HDSS [...] factors for fatal foetal outcomes. RESULTS: A total of 2976 pregnancies were monitored of which 118 (4.0%) resulted in a fatal outcome. Risk factors identified by multivariable logistic regression analysis

6. Activity of diphenyl ether benzyl amines against human African trypanosomiasis (Publications)

   Activity of diphenyl ether benzyl amines against human African trypanosomiasis

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   a number of functionally simple diphenyl ether analogs which give low micromolar activity (IC50 = 0.16-0.96 muM) against T. b. rhodesiense. The best compound shows favorable selectivity against the L6 cell

7. A large scale gene-centric association study of lung function in newly-hired female cotton textile workers with endotoxin exposure (Publications)

   A large scale gene-centric association study of lung function in newly-hired female cotton textile workers with endotoxin exposure

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   permutation method. The false discovery rate (FDR) and the family-wise error rate (FWER) were set to be 0.10 and 0.15 respectively. RESULTS: Two SNPs were found to be significant (P

8. The epidemiology of residual <em>Plasmodium falciparum</em> malaria transmission and infection burden in an African city with high coverage of... (Publications)

   The epidemiology of residual <em>Plasmodium falciparum</em> malaria transmission and infection burden in an African city with high coverage of multiple vector control measures

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   thuringiensis var. israelensis (Bti) had no effect upon either vector density (P = 0.820) or infection prevalence (P = 0.325) when managed by a private-sector contractor. Infection prevalence rebounded back

9. Occurrence of <em>Giardia lamblia</em> in recreational streams in Basel-Landschaft, Switzerland (Publications)

   Occurrence of <em>Giardia lamblia</em> in recreational streams in Basel-Landschaft, Switzerland

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   cysts, given a concentration of E. coli or enterococci, did not prove to be suitable (r-squared=0.27; r-squared=0.24)

10. Antitrypanosomal quinoline alkaloids from the roots of <em>Waltheria indica</em> (Publications)

    Antitrypanosomal quinoline alkaloids from the roots of <em>Waltheria indica</em>

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    showed potent and selective growth inhibition toward Trypanosoma cruzi with IC50 values between 0.02 and 0.04 muM. Cytotoxicity for mouse skeletal L-6 cells was also determined for these compounds