Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern Uganda (Publications)
3483 clinically suspect patients, 53% were confirmed with primary VL. Sixty-two per cent were children 0.20). The main risk factors for in-hospital death identified by a multivariate analysis were age 15 years [...] ed adverse events. The case-fatality rate among patients > 45 years of age was strikingly high (29.0%). CONCLUSION: Subgroups of VL patients at higher risk of death during treatment with drugs currently
Optimization of novel 1-methyl-1 h-pyrazole-5-carboxamides leads to high potency larval development inhibitors of the barber's pole worm (Publications)
contortus led to the identification of a 1-methyl-1 H-pyrazole-5-carboxamide derivative with an IC50 of 0.29 muM. Medicinal chemistry optimization targeted modifications on the left-hand side (LHS), middle [...] the most potent compound, inhibiting the development of the fourth larval (L4) stage with an IC50 of 0.01 muM. In contrast, only 18% inhibition of the mammary epithelial cell line MCF10A viability was observed
A large scale gene-centric association study of lung function in newly-hired female cotton textile workers with endotoxin exposure (Publications)
permutation method. The false discovery rate (FDR) and the family-wise error rate (FWER) were set to be 0.10 and 0.15 respectively. RESULTS: Two SNPs were found to be significant (P
The epidemiology of residual <em>Plasmodium falciparum</em> malaria transmission and infection burden in an African city with high coverage of... (Publications)
thuringiensis var. israelensis (Bti) had no effect upon either vector density (P = 0.820) or infection prevalence (P = 0.325) when managed by a private-sector contractor. Infection prevalence rebounded back
Occurrence of <em>Giardia lamblia</em> in recreational streams in Basel-Landschaft, Switzerland (Publications)
cysts, given a concentration of E. coli or enterococci, did not prove to be suitable (r-squared=0.27; r-squared=0.24)
Antitrypanosomal quinoline alkaloids from the roots of <em>Waltheria indica</em> (Publications)
showed potent and selective growth inhibition toward Trypanosoma cruzi with IC50 values between 0.02 and 0.04 muM. Cytotoxicity for mouse skeletal L-6 cells was also determined for these compounds
Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern Uganda (Publications)
3483 clinically suspect patients, 53% were confirmed with primary VL. Sixty-two per cent were children 0.20). The main risk factors for in-hospital death identified by a multivariate analysis were age 15 years [...] ed adverse events. The case-fatality rate among patients > 45 years of age was strikingly high (29.0%). CONCLUSION: Subgroups of VL patients at higher risk of death during treatment with drugs currently
Optimization of novel 1-methyl-1 h-pyrazole-5-carboxamides leads to high potency larval development inhibitors of the barber's pole worm (Publications)
contortus led to the identification of a 1-methyl-1 H-pyrazole-5-carboxamide derivative with an IC50 of 0.29 muM. Medicinal chemistry optimization targeted modifications on the left-hand side (LHS), middle [...] the most potent compound, inhibiting the development of the fourth larval (L4) stage with an IC50 of 0.01 muM. In contrast, only 18% inhibition of the mammary epithelial cell line MCF10A viability was observed
Activity of diphenyl ether benzyl amines against human African trypanosomiasis (Publications)
a number of functionally simple diphenyl ether analogs which give low micromolar activity (IC50 = 0.16-0.96 muM) against T. b. rhodesiense. The best compound shows favorable selectivity against the L6 cell
Genome-wide association study of body mass index in 23,000 individuals with and without asthma (Publications)
not significant in the total replication data set, P = 0.71. Using a random effects model, BMI was overall estimated to increase by 0.30 kg/m(2) (P = 0.01 for combined screening and replication data sets [...] 2014 asthmatics, and rs4915551 was nominally replicated (P < 0.05) in two of the seven studies and of borderline significance in one (P = 0.059). However, strong evidence of effect heterogeneity was observed
