Pharmacokinetics of a novel piperaquine dispersible granules formulation under fasting and various fed conditions versus piperaquine tablets when... (Publications)
relative exposure of PQP granules versus the tablet was 73.9% (90% CI 48.3, 113.0) for C(max) and 86.5% (68.2, 109.6) for AUC(0-t). Following a typical East African low-fat meal, a standard high-fat meal, [...] 391), and 294% (203, 425) for C(max) and 164% (124, 217), 184% (148, 228), and 195% (147, 259) for AUC(0-t), respectively. Both formulations were well tolerated with one drug-related adverse event (moderate
Gestational SARS-CoV-2 infection in a Ugandan birth cohort: high incidence, mild maternal disease, and evidence of association with transient infant... (Publications)
Z-score at age 3 months compared with no infection or late pregnancy infect (-1.54 versus -0.37 and -0.51, P = 0.009). These findings suggest that pregnant Ugandan women experienced high levels of SARS-CoV-2
Antibiotics in pregnancy influence nasal microbiome and respiratory morbidity in infancy (Publications)
year of life (risk ratio 1.38, 95% CI 1.03-1.84; adjusted p-value (p(adj))=0.032 and risk ratio 1.75, 95% CI 1.02-2.97; p(adj)=0.041, respectively), but not with wheeze or atopy in childhood. However, we [...] lower in infants with antibiotic exposure compared to nonexposed infants (e.g. Shannon index p-value 0.006). Prenatal antibiotic exposure was also associated with a higher risk of any, as well as severe
Transitioning to dolutegravir in a programmatic setting: virological outcomes and associated factors among treatment-naive patients with HIV-1 in the... (Publications)
reverse transcriptase inhibitor (NRTI), NNRTI, and protease inhibitors resistance was detected in 0 (0%), 2 (14%) and 1 (7%), respectively. No resistance was found in the 2 of 30 participants with available [...] for 165/195 (85%) and 154/211 (73%) participants in the DTG- and NNRTI- cohorts, respectively (P = 0.003). DTG-based ART was associated with > 2 times the odds of viral suppression versus NNRTI-based ART
Decreasing incidence of conjunctival squamous cell carcinoma in people with HIV in South Africa (Publications)
S-34 degrees S had a 49% lower SCCC risk than those residing at < 25 degrees S (adjusted HR 0.67; 95% CI 0.55-0.82). Other risk factors for SCCC were lower CD4 counts and middle-age. There was no evidence
Predicting fine-scale daily NO2 over Mexico City using an ensemble modeling approach (Publications)
the 200-m2 scale. The cross-validated R2 of the RF and XGBoost models in stage 2 were 0.75 and 0.86 respectively, and 0.87 for the ensembled GAM. Cross-validated root-mean-squared error (RMSE) of the GAM
Childhood cancer and traffic-related air pollution in Switzerland: a nationwide census-based cohort study (Publications)
for AML. The adjusted HR for exposure to benzene per 1 mug/m(3) was 1.03 (95%-CI 0.86-1.23) for ALL and 1.29 (95%-CI 0.86-1.95) for AML. We also observed increased HRs for other diagnostic groups, notably [...] hazard ratios (HR) and 95% confidence intervals for exposure to NO2 per 10 mug/m(3) were 1.00 (95%-CI 0.88-1.13) for acute lymphoblastic leukemia (ALL) and 1.31 (95%-CI 1.00-1.71) for acute myeloid leukemia
Depression and cardiovascular disease are not linked by high blood pressure: findings from the SAPALDIA cohort (Publications)
08 mmHg/10 years, 95% CI - 4.09 to - 0.07) compared to non-depressed. A similar trend was observed with diastolic BP (beta = - 0.88 mmHg/10 years, 95% CI - 2.15 to 0.39), albeit weaker and not statistically
Pollen exposure is associated with risk of respiratory symptoms during the first year of life (Publications)
009]; tree 1.005 [1.002, 1.008]; grass 1.009 [1.000, 1.23]) and nighttime (combined 1.003 [0.999, 1.007]; tree 1.003 [0.999, 1.007]; grass 1.014 [1.004, 1.024]). While there was no effect modification by maternal [...] infant's sex, a complex crossover interaction between combined pollen and PM2.5 was found (p-Value 0.002). CONCLUSION: Even as early as during the first year of life, pollen exposure was associated with
Cross-sectional study of nutritional intake among patients undergoing tuberculosis treatment along the Myanmar-Thailand border (Publications)
tly higher proportion of women (8/8, 100%) met caloric requirements compared with men (9/20, 45.0%, p=0.010), but few participants met other macronutrient or micronutrient requirements, with no significant [...] weight gain of 6.48 kg (95% CI: 3.87 to 9.10) and increased BMI of 2.47 kg/m(2) (95% CI: 1.45 to 3.49; p=0.0001 for both). However, 50% (14/28) still had mild or more severe forms of malnutrition. CONCLUSIONS:
