Leprosy and cutaneous leishmaniasis affecting the same individuals: a retrospective cohort analysis in a hyperendemic area in Brazil (Publications)
detected that the probability of a patient developing both diseases increased over time from 0.2% in the first year to 1.0% within seven years. Further, using a Cox model we identified male sex (HR: 2.3; 95% CI: [...] From the leprosy (n = 28,204) and CL (n = 24,771) databases of the national reporting system, 414 (0.8%; 414/52,561) patients presenting both diseases were identified through a probabilistic linkage procedure
Optimizing moxidectin dosing for <em>Strongyloides stercoralis</em> infections: insights from pharmacometric modeling (Publications)
ion time curve-receiver operating characteristic [AUC-ROC] 0.817) in the probability of being cured by linking an exposure metric (i.e., AUC0-24 or maximum concentration [Cmax ]) to baseline infection [...] maximum cure rate of ~ 95% is established in the low infection intensity group (larvae per gram [LPG] > /=0.4-1), whereas in the moderate-to-high intensity group (LPG > 1) the cure rate plateaus at ~ 87%, following
Assessment of fecal calprotectin and fecal occult blood as point-of-care markers for soil-transmitted helminth attributable intestinal morbidity in a... (Publications)
co-infection and FC concentration, while an inverse association (odds ratio (OR): 0.45, 95% credible intervals (CrI): 0.26, 0.75) was found between hookworm co-infection and FC concentration. In Lao PDR, the
A satellite-based spatio-temporal machine learning model to reconstruct daily PM2.5 concentrations across Great Britain (Publications)
cross-validated R2 of 0.767 and minimal bias. The model performed better over the temporal scale when compared to the spatial component, but both presented good accuracy with an R2 of 0.795 and 0.658, respectively
Immunogenicity and protective efficacy of radiation-attenuated and chemo-attenuated PfSPZ vaccines in Equatoguinean adults (Publications)
14 weeks after last PfSPZ-CVac dose was 55% (8 of 13, P = 0.051) and at a median of 15 weeks after last PfSPZ Vaccine dose was 27% (5 of 15, P = 0.32). The higher VE in PfSPZ-CVac recipients of 55% with [...] CHMI of three doses of 2.7 x 10(6) PfSPZ of PfSPZ Vaccine at 8-week intervals and three doses of 1.0 x 10(5) PfSPZ of PfSPZ-CVac at 4-week intervals with each arm randomized, double-blind, placebo-controlled
Outcomes of antiretroviral treatment programs in rural Southern Africa (Publications)
and 25.4% (24.0%-26.9%), respectively, with important differences between countries as follows: in Zimbabwe 75.1% (72.8%-77.3%) were alive and on ART at 3 years compared with 55.4% (52.8%-58.0%) in Lesotho [...] Lesotho and 51.6% (48.0%-55.2%) in Mozambique. In all settings, young age and male gender predicted LTFU, whereas advanced clinical stage and low baseline CD4 counts predicted death. CONCLUSIONS: In African
Rifampicin/Cotrimoxazole/Isoniazid versus mefloquine or quinine + sulfadoxine- pyrimethamine for malaria: a randomized trial1 (Publications)
higher for Cotrifazid than for mefloquine or quinine + SP (9% [PCR corrected 8%] versus 0% and 3%, respectively [p = 0.02]). CONCLUSION: Despite what appears to be short-term clinical equivalence, the notable [...] clinical failure rate (symptoms and parasite load) on day 14 was equivalent for the three groups (0% for Cotrifazid and mefloquine; 1% for quinine + SP), but parasitological failure rate (P. falciparum
The effect of egg embryonation on field-use of a hookworm benzimidazole-sensitivity egg hatch assay in Yunnan province, People's Republic of... (Publications)
37 stool samples received from local school-aged children. The mean IC(50) was 0.10 ug/ml thiabendazole (95% CIs: 0.09-0.12 ug/ml). Observation of the eggs immediately prior to assay set-up revealed that
Co-infection of HIV and intestinal parasites in rural area of China (Publications)
prevalences among HIV positives were as follows: 3.6% for hookworm, 0.7% for Trichuris trichiura, zero for Ascaris lumbricoides, 0.3% for Clonorchis sinensis, 1.3% for Giardia intestinalis, 16.2% for [...] were significantly more prevalent among HIV positives (8.3%) compared to the HIV negative group (3.0%; P
Assessing the presence of <em>Wuchereria bancrofti</em> in vector and human populations from urban communities in Conakry, Guinea (Publications)
the LAMP assay revealed that 1.8 % of An. gambiae and 0.31 % of Culex spp. were positive, while PCR determined respective prevalences of 0 % and 0.19 %. CONCLUSIONS: This study revealed the presence of
