Two new rapid SNP-typing methods for classifying <em>Mycobacterium tuberculosis</em> complex into the main phylogenetic lineages (Publications)
ed strains into the main phylogenetic lineages. The sensitivity in allele-calling was 98.6% and 98.8% for MOL-PCR and TaqMan, respectively. Typing of an additional panel of 78 unknown clinical isolates
Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis (Publications)
some animals relapsed during the 300 days of post treatment monitoring, resulting in a cure rate of 3/8 (37.5%) and 3/7 (42.9%) for the 5 mg/kg×10 days and the 6 mg/kg×14 days dose regimens respectively.
Strategies for detection of <em>Plasmodium species</em> gametocytes (Publications)
transcripts. RNA-based parasite detection resulted in a P. falciparum positivity of 24.1%; of these 40.8% carried gametocytes. P. vivax positivity was 38.4%, with 38.0% of these carrying gametocytes. Sensitivity
An experimental hut study to quantify the effect of DDT and airborne pyrethroids on entomological parameters of malaria transmission (Publications)
coils, Metofluthrin coils and DDT reduced human vector contact through deterrence by 38%, 30% and 8%, respectively and induced half of the mosquitoes to leave huts before feeding (56%, 55% and 48%, r
Estimating the global burden of endemic canine rabies (Publications)
human deaths, over 3.7 million (95% CIs: 1.6-10.4 million) disability-adjusted life years (DALYs) and 8.6 billion USD (95% CIs: 2.9-21.5 billion) economic losses annually. The largest component of the economic
Quantitative whole-cell MALDI-TOF MS fingerprints distinguishes human monocyte sub-populations activated by distinct microbial ligands (Publications)
CD16(-) monocytes, versus autologous CD16(+) subpopulations from the blood of healthy human donors (n?=?8) and compared their inflammatory properties in response to lipopolysaccharides and M.tuberculosis antigens
Mycolactone-dependent depletion of endothelial cell thrombomodulin is strongly associated with fibrin deposition in Buruli ulcer lesions (Publications)
of human dermal microvascular endothelial cells (HDMVEC) at doses as low as 2ng/ml and as early as 8hrs after exposure. TM activates protein C by altering thrombin's substrate specificity, and exposure
Assessing the presence of <em>Wuchereria bancrofti</em> in vector and human populations from urban communities in Conakry, Guinea (Publications)
none was infected with any stage of the W. bancrofti parasite. However, the LAMP assay revealed that 1.8 % of An. gambiae and 0.31 % of Culex spp. were positive, while PCR determined respective prevalences
Health worker compliance with a 'test and treat' malaria case management protocol in Papua New Guinea (Publications)
prescribed an antimalarial. Overall compliance with a strictly defined test and treat protocol was 62.8%. A reluctance to test current/recently febrile patients for malaria infection by RDT or microscopy
How important is the angle of tilt in the WHO cone bioassay? (Publications)
RESULTS: Mosquitoes spent more time on the net at 60 degrees as compared to 0 degrees (coefficient = 45.8, 95 % CI 34.6-55.6, p < 0.001) and were more likely to die when the test was done at 45 degrees (OR
