Differential gene repertoire in <em>Mycobacterium ulcerans</em> identifies candidate genes for patho-adaptation (Publications)
approximately 7% of the entire M. ulcerans genome. PRINCIPAL FINDINGS: Several different mechanisms leading to loss of functional genes were identified, ranging from pseudogenization, caused by frame shift [...] the classical lineage may contribute to particular virulence of this group comprising isolates from Africa and Australia. Identification of this spectrum of anti-virulence gene candidates expands our und
Schistosomiasis in European travelers and migrants: analysis of 14 years TropNet Surveillance Data (Publications)
(22%) cases; 57.5% of patients were symptomatic. Acute symptoms were reported in 27% of patients leading to earlier presentation within 3 months. Praziquantel was used in all patients to treat schistosomiasis [...] Travelers should be made aware of the risk of schistosomiasis infection when traveling to sub-Saharan Africa. Posttravel consultations particularly for returning expatriates are useful given the high potential
Adaptation to Climate Change in West Africa Swiss TPH experts deployed an eco-health approach to analyse people's adaption to climate change in four secondary cities in West Africa. The first phase of the project [...] patient data in Limpopo province, South Africa Climate change and respiratory diseases: state and exploratory analyses of patient data in Limpopo province, South Africa PoCHAS - Effects of airborne pollen [...] change are manifold. Swiss TPH experts study the health impact of...
approaches to understand the increasing burden of cardio-metabolic diseases in sub-Saharan Africa. Eze leads and collaborates on numerous epidemiological studies integrating biomarkers to improve mechanistic [...] Officer of Novartis’s Sub-Saharan Africa region. He and his team are responsible for driving the Commercial Strategy and execution of Novartis’s Sub-Saharan Africa mandate, with the goal of expanding [...] Initiatives for scaling up access. de Savigny has lived and worked for many...
Association between the proportion of <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> infections detected by passive surveillance and the... (Publications)
facilities. P(Detect) was estimated using a Bayesian model in 431 clusters spanning the Americas, Africa, and Asia. The association between P(Detect) and malaria prevalence was assessed using log-linear [...] is sufficiently low. The likely explanation for P falciparum is that reduced exposure to infection leads to lower levels of protective immunity in the population, increasing the likelihood that infected [...] enhancing access to care and improvements in care-seeking behaviour of infected...
Association between the proportion of <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> infections detected by passive surveillance and the... (Publications)
facilities. P(Detect) was estimated using a Bayesian model in 431 clusters spanning the Americas, Africa, and Asia. The association between P(Detect) and malaria prevalence was assessed using log-linear [...] is sufficiently low. The likely explanation for P falciparum is that reduced exposure to infection leads to lower levels of protective immunity in the population, increasing the likelihood that infected [...] enhancing access to care and improvements in care-seeking behaviour of infected...
Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis... (Publications)
Lower back and neck pain was the leading global cause of disability in 2015 in most countries. The leading cause was sense organ disorders in 22 countries in Asia and Africa and one in central Latin America; [...] The second and third leading impairments by number of individuals affected were hearing loss and vision loss, respectively. Between 2005 and 2015, there was little change in the leading causes of years lived [...] lived with disability (YLDs) on a global basis. NCDs accounted for 18 of...
Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of... (Publications)
3 million]). In 2016 in 113 countries, the leading risk factor in terms of attributable DALYs was a metabolic risk factor. Smoking remained among the leading five risk factors for DALYs for 109 countries [...] countries, while low birthweight and short gestation was the leading risk factor for DALYs in 38 countries, particularly in sub-Saharan Africa and South Asia. In terms of important drivers of change in trends [...] change significantly for four risks, and decreased significantly for 31...
Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis... (Publications)
Lower back and neck pain was the leading global cause of disability in 2015 in most countries. The leading cause was sense organ disorders in 22 countries in Asia and Africa and one in central Latin America; [...] The second and third leading impairments by number of individuals affected were hearing loss and vision loss, respectively. Between 2005 and 2015, there was little change in the leading causes of years lived [...] lived with disability (YLDs) on a global basis. NCDs accounted for 18 of...
Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of... (Publications)
3 million]). In 2016 in 113 countries, the leading risk factor in terms of attributable DALYs was a metabolic risk factor. Smoking remained among the leading five risk factors for DALYs for 109 countries [...] countries, while low birthweight and short gestation was the leading risk factor for DALYs in 38 countries, particularly in sub-Saharan Africa and South Asia. In terms of important drivers of change in trends [...] change significantly for four risks, and decreased significantly for 31...
