Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against... (Publications)
6-77.4]; egg reduction 99.2%, 98.7-99.6) and albendazole plus ivermectin (30 of 109 cured [27.5%, 19.0-36.0]; egg reduction 94.5%, 91.7-96.3) were significantly more effective against T trichiura than mebendazole [...] plus mebendazole had similar low efficacy (nine of 107 cured [8.4%, 3.1-13.8; egg reduction 51.6%, 35.0-65.3) to mebendazole alone. About a fifth of the children reported adverse events, which were mainly [...] headache were the most common adverse events after treatment;...
Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical... (Publications)
short-term vs conventional treatment group were 0.95 (90% CI, 0.70 to 1.29; P = .006 for noninferiority) in the intention-to-treat analysis and 0.93 (90% CI, 0.68 to 1.26; P = .005 for noninferiority) in the
Defining risk-based monitoring frequencies to verify the performance of water treatment barriers (Publications)
show that a failure of 15 s should be reliably detected to verify a log reduction value (LRV) of 6.0; thus, detecting and remediating these failures may be beyond current technology. For chemical disinfection [...] a residual, failure durations in order of minutes should be reliably detected to verify a LRV of 6.0. Short-term failures are buffered because the disinfectant residual concentration sustains a partial
Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and <em>in vivo</em> efficacy in a... (Publications)
ion of a highly potent 3-trifluoromethyl-1,2,4-oxadiazole analogue 23 (PfNF54 IC(50) = 0.012 muM; PfK1 IC(50) = 0.040 muM) displaying high microsomal metabolic stability (HLM CL(int) < 11.6 muL.min(-1)
New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities (Publications)
against a chloroquine-sensitive strain (IC50(NF54) = 0.019 microM) and even higher antiplasmodial activity against a multiresistant strain (IC50(K1) = 0.007 microM). Compared to the MMV compound, the permeability
Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of household recent TB... (Publications)
(4/10) were MDR-TB strains. Recurrent TB was attributed to relapse (same strain) in 75.0% (27/36) of participants with 25.0% (9/36) attributed to re-infection. CONCLUSION: Our findings indicate that unresolved
Regional differences of physical activity and sedentary behaviour in Swiss children are not explained by socio-demographics or the built environment (Publications)
less sedentary (by 10-15 %, p < 0.01). Although German-speaking children lived in a more favourable environment and a higher socioeconomic neighbourhood (differences p < 0.001), these characteristics did
A community-randomized evaluation of the effect of intermittent preventive treatment in infants on antimalarial drug resistance in southern Tanzania (Publications)
areas. This was accompanied by an increase in dhfr, but not dhps, mutations in IPTi areas (p=0.004 and p=0.18 respectively).Conclusions. IPTi did not increase drug pressure, or the selection on dhfr and
Potential impact of climate change on schistosomiasis transmission in China (Publications)
the mean January temperature is above 0 degrees C. The combination of these temperature thresholds, together with our own predicted temperature increases in China of 0.9 degrees C in 2030 and 1.6 degrees
KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment and prevention of disease transmission (Publications)
strains as well as potent therapeutic activity in a mouse models of malaria with ED50/90/99 values of 0.6/0.9/1.4 mg/kg respectively. When administered prophylactically in a sporozoite challenge mouse model
