Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of household recent TB... (Publications)
(4/10) were MDR-TB strains. Recurrent TB was attributed to relapse (same strain) in 75.0% (27/36) of participants with 25.0% (9/36) attributed to re-infection. CONCLUSION: Our findings indicate that unresolved
Regional differences of physical activity and sedentary behaviour in Swiss children are not explained by socio-demographics or the built environment (Publications)
less sedentary (by 10-15 %, p < 0.01). Although German-speaking children lived in a more favourable environment and a higher socioeconomic neighbourhood (differences p < 0.001), these characteristics did
A community-randomised evaluation of the effect of IPTi on anti-malarial drug resistance in southern Tanzania (Publications)
areas. This was accompanied by an increase in dhfr, but not dhps, mutations in IPTi areas (p=0.004 and p=0.18 respectively).Conclusions. IPTi did not increase drug pressure, or the selection on dhfr and
Potential impact of climate change on schistosomiasis transmission in China (Publications)
the mean January temperature is above 0 degrees C. The combination of these temperature thresholds, together with our own predicted temperature increases in China of 0.9 degrees C in 2030 and 1.6 degrees
KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment and prevention of disease transmission (Publications)
strains as well as potent therapeutic activity in a mouse models of malaria with ED50/90/99 values of 0.6/0.9/1.4 mg/kg respectively. When administered prophylactically in a sporozoite challenge mouse model
Problematic mobile phone use in adolescents: derivation of a short scale MPPUS-10 (Publications)
highly reflects the original MPPUS (Kendalls' Tau: 0.80 with 90% concordant pairs). Internal consistency of MPPUS-10 was good with Cronbach's alpha: 0.85. The results were confirmed using the follow-up
Sleep quality and the risk of work injury: a Swiss case-control study (Publications)
sleep quality was associated significantly with work injury of any type (P < 0.05) and with being caught in particular (P < 0.05). The association between poor sleep quality and work injury was significantly
Antimalarial Pyrido[1,2-a]benzimidazoles (Publications)
activity vs the drug-resistant K1 strain of Plasmodium falciparum relative to chloroquine (IC(50) = 0.047 muM v 0.17 muM); potency was retained against a range of drug-sensitive and drug-resistant strains, with
Development of amplicon deep sequencing markers and data analysis pipeline for genotyping multi-clonal malaria infections (Publications)
"HaplotypR" was developed for data analysis. RESULTS: Cpmp was highly diverse (He = 0.96) in contrast to csp (He = 0.57). Minority clones were robustly detected if their frequency was > 1%. False haplotype
Time to change focus? Transitioning from higher neonatal to higher stillbirth mortality in São Paulo State, Brazil (Publications)
ended in stillbirth (fetal death > 22 weeks gestation or fetal weight > 500g), but this varied from 0.0 to 28.4 per 1000 across municipalities. 7.9 per 1000 live births also died within the first 28 days
