Development and validation of an LC-MS/MS method for the quantification of the anthelmintic drug moxidectin in a volumetric absorptive microsample,... (Publications)
Moxidectin was detected by multiple reaction monitoring (640.4 --> 528.5 m/z) using a Luna C8(2) (30 x 2.0 mm, 3 microm particle size, 100 A) analytical column with a gradient program of 6 min duration. Validation [...] selectivity, linearity, stability, recovery, and haematocrit influence with a limit of quantification of 0.5 and 2.5 ng/mL, for venous and capillary blood respectively. Moxidectin was stable up to 2 months at [...] different matrixes and sampling strategies: e.g. identical time...
Semi-field evaluation of freestanding transfluthrin passive emanators and the BG sentinel trap as a "push-pull control strategy" against <em>Aedes... (Publications)
aegypti (P = 0.30). The FTPE offered significant protection against Ae. aegypti at month three, with a PE of 46.4% (95% CI: 41.1-51.8%), but not at six months with a PE of 2.2% (95% CI: -9.0-14.0%). CONCLUSIONS:
First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children (Publications)
clinical malaria in the first 6000 children in the older age category was 0.32 episodes per person-year in the RTS,S/AS01 group and 0.55 episodes per person-year in the control group, for an efficacy of 50 [...] rate of generalized convulsive seizures after RTS,S/AS01 vaccination was 1.04 per 1000 doses (95% CI, 0.62 to 1.64). Conclusions The RTS,S/AS01 vaccine provided protection against both clinical and severe
LUR models for particulate matters in the Taipei metropolis with high densities of roads and strong activities of industry, commerce and construction (Publications)
concentrations of PM2.5, PM10, and PMcoarse were 26.0±5.6, 48.6±5.9, and 23.3±3.1?g/m3, respectively, and the absorption coefficient of PM2.5 was 2.0±0.4×10-5m-1. Our LUR models yielded R2 values of 95%
Diagnostic accuracy of Kato-Katz and FLOTAC for assessing anthelmintic drug efficacy (Publications)
Trichuris trichiura (95% vs. 88%, p = 0.012) and Ascaris lumbricoides (88% vs. 68%, p = 0.098), but a lower sensitivity for hookworm diagnosis (54% vs. 81%, p = 0.006). Considering the combined results
Intestinal parasite prevalence in an area of Ethiopia after implementing the SAFE strategy, enhanced outreach services, and health extension program (Publications)
6-3.7%), respectively. The prevalence of S. mansoni was 2.9% (95% CI 0.2-5.5%) but infection was highly focal (range by community from 0-52.4%). The prevalence of any of these helminth infections was 24.2% [...] pathogenic intestinal protozoa Giardia intestinalis and Entamoeba histolytica/E. dispar were found in 23.0% (95% CI 20.3-25.6%) and 11.1% (95% CI 8.9-13.2%) of the surveyed children, respectively. We found
Use of insecticide quantification kits to investigate the quality of spraying and decay rate of bendiocarb on different wall surfaces in Kagera... (Publications)
proportion of samples meeting WHO standards varied between Karagwe (84.3%) and Muleba (96.3%) (p < 0.001). Assessment of quality of spraying at house level revealed that Muleba (84.8%) had a significantly [...] of households that met the expected target dosage (100-400 mg/m2) compared to Karagwe (68.9%) (p < 0.001). The quality of spraying varied across different wall substrates in both districts. Evaluation [...] declined from 96.9%, 93.5% and 76.2% at months one, two, and three post IRS,...
Identification of oleamide in <em>Guatteria</em> recurvisepala by LC/MS-Based <em>Plasmodium falciparum</em> thioredoxin reductase ligand binding... (Publications)
retention time of 17.95 min in a 20-min gradient of 95 % B consisting of (A) 0.1 % formic acid in 95 % H (2)O-5 % ACN, and (B) 0.1 % formic acid in 95 % ACN-5% H (2)O in an LC-QTOF-MS. Tandem MS of the protonated [...] (DBE: 2; error: 1.13 ppm) resulted in two daughter ions M/Z 265.2516 [M + H-NH (3)] (+) (DBE: 3; error: 0.35 ppm) and M/Z 247.2405 [M + H-NH (3)-H (2)O] (+), (DBE: 4; error: 2.26 ppm). The PFTrxR ligand was
Efficacy of praziquantel against <em>Schistosoma mekongi </em>and <em>Opisthorchis viverrini</em>: a randomized, single-blinded dose-comparison trial (Publications)
respectively. S. mekongi cure rates were 75.0% (95% confidence interval (CI): 56.6-88.5%) and 80.8% (95% CI: 60.6-93.4%) for 40 mg/kg and 75 mg/kg PZQ, respectively (P = 0.60). O. viverrini cure rates were si [...] significantly different at 71.4% (95% CI: 53.4-84.4%) and 96.6% (95% CI: not defined), respectively (P = 0.009). Egg reduction rates (ERRs) against O. viverrini were very high for both doses (> 99%), but slightly
Isolation of nontuberculous <em>Mycobacteria</em> from the environment of Buruli ulcer endemic communities in Ghana (Publications)
species in the various environmental samples analysed were: soil 16 (43.2 %), vegetation 14 (38.0 %), water 3 (8.0 %), moss 2 (5.4%), snail 1 (2.7 %) and fungi 1 (2.7 %). CONCLUSION: This study is the first [...] decontamination by 1M NaOH followed by 5% oxalic acid gave the highest recovery of mycobacteria (50.0%) and the least contamination (15.6%). The cultivating medium that supported the highest recovery of
