Isothermal microcalorimetry to study the activity of triclabendazole and its metabolites on juvenile and adult <em>Fasciola hepatica</em> (Publications)
and triclabendazole sulphoxide showed no movements 8.3, 35 and 6 hours post-incubation (all p 0.05) and 88 (p> 0.05) hours. In conclusion, IMC is useful to document drug effects on juvenile F. hepatica and
Klinik und Epidemiologie der Kryptosporidiose bei immunkompetenten Kindern (Publications)
longer than the period of diarrhoea (p = 0.02). Compared with control patients suffering from diarrhoea of other origin, respiratory symptoms were significantly (p = 0.02) more frequent in children with c
Antiprotozoal activity of <em>Achillea ptarmica</em> (Asteraceae) and its main alkamide constituents (Publications)
(sneezewort yarrow) was found to be active in vitro against Trypanosoma brucei rhodesiense (IC50 = 0.67 microg/mL) and Plasmodium falciparum (IC50 = 6.6 mug/mL). Bioassay guided fractionation led to the [...] 3.3 microg/mL), while 8,9-Z-dehydropellitorine was most active against T. b. rhodesiense (IC50 = 2.0 microg/mL). The activity of pure pellitorine against Plasmodium is higher than that of the crude extract
Quantitative structure: antiprotozoal activity relationships of sesquiterpene lactones (Publications)
activity, especially against T. brucei (e.g. helenalin and some of its esters with IC(50)-values of 0.05-0.1 microM, which is about 10 times lower than their cytotoxic activity). It was found that all in
Spatial distribution of<em> Falciparum</em> malaria infections in Zanzibar: implications for focal drug administration strategies targeting... (Publications)
from a population-based survey in 3 adjacent communities. Results.: Among 5278 persons screened, 13 (0.2%) were positive by RDT and 123 (2.3%) by PCR. PCR-positive individuals were scattered over the study [...] confidence interval, 2.8-19.9) for those living in the household of an RDT-positive individual and 1.64 (1.0-2.8; P = .06) for those living within 1000 m. Treating everyone within households of RDT-positive i
Circulating alpha1-antitrypsin in the general population: determinants and association with lung function (Publications)
inverse association of AAT with FEV1 in the total study population (p < 0.001), that disappeared after adjustment for CRP (p = 0.28). In addition, the AAT and FEV1 association was modified by gender,
A controlled trial to reduce the risk of human Nipah virus exposure in Bangladesh (Publications)
consuming raw sap from a protected source than those with no exposure (25 vs. 15%, OR 2.0, 95% CI 1.5-2.6, P < 0.001). While the intervention increased knowledge in both intervention areas, the "only safe
Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho (Publications)
and combined nasal and nasopharyngeal Ag-RDT result was 70.2% (95%CI: 61.3-78.0), 67.3% (57.3-76.3) and 74.4% (65.5-82.0), respectively. The respective specificity was 97.9% (97.1-98.4), 97.9% (97.2-98
Synthesis and structure-activity relationships of new 2-phenoxybenzamides with antiplasmodial activity (Publications)
high antiplasmodial activity against P. falciparum NF54 (PfNF54 IC50 = 0.2690 M) and very low cytotoxicity (L-6 cells IC50 = 124.0 M) resulting in an excellent selectivity index of 460. Compared to the
<em>In vitro, in vivo</em>, and ADME evaluation of SF5-containing <em>N,N'</em>-diarylureas as antischistosomal agents (Publications)
l group. Low IC(50) values for Schistosoma mansoni newly transformed schistosomula (0.6 - 7.7 μM) and adult worms (0.1 - 1.6 μM) were observed. Four selected compounds, highly active in presence of albumin
