Evaluation of a duplex real-time PCR in human serum for simultaneous detection and differentiation of <em>Schistosoma mansoni</em> and <em>Schistosoma... (Publications)
between the compared diagnostic procedures at genus level was fair (kappa 0.273) if serology was included and moderate (kappa 0.420) if serology was not included. DISCUSSION: The PCR assay proved to be
The safety and efficacy of sulfadoxine-pyrimethamine, amodiaquine, and their combination in the treatment of uncomplicated <em>Plasmodium... (Publications)
laboratory parameters. Children receiving SP were more likely to vomit during follow-up (32% vs. 17%: P = 0.03), and SP alone resulted in prolonged fever clearance times. Although Day 7 and Day 14 clinical and [...] of AQ, and reduced the incidence of gametocytemia during follow-up (AQ+SP 12.6% vs. SP 29.9%; P = 0.001). The level of R1 resistance to SP may herald a rapid decline in its efficacy as SP drug pressure
Consistency in preventing voluntary dehydration in boys who drink a flavored carbohydrate-NaCl beverage during exercise in the heat (Publications)
humidity. Subjects drank grape-flavored solution with 6% carbohydrate (2% glucose, 4% sucrose) and 18.0 mmol.L-1 NaCl ad libitum. Body weight (BW), heart rate, rectal temperature, thirst, and stomach fullness [...] were no differences among the six sessions in voluntary drink intake (765-902 g), hydration level (+0.75 to +1.07%BW), sweating rate (245-263 g.m-2.hr-1), and the other physiological and perceptual variables
Exposure to ozone gases in pulp mills and the onset of rhinitis (Publications)
workers. Bleachery workers without self-reported ozone gassings were not at increased risk (HR 0.9, 95% CI 0.3-2.4). CONCLUSION: Acute exposure to high levels of ozone increases the risk of noninfectious
The global burden of disease due to outdoor air pollution (Publications)
respiratory infections in children under 5 yr, worldwide. This amounts to about 0.8 million (1.2%) premature deaths and 6.4 million (0.5%) years of life lost (YLL). This burden occurs predominantly in developing
Isothermal microcalorimetry to study the activity of triclabendazole and its metabolites on juvenile and adult <em>Fasciola hepatica</em> (Publications)
and triclabendazole sulphoxide showed no movements 8.3, 35 and 6 hours post-incubation (all p 0.05) and 88 (p> 0.05) hours. In conclusion, IMC is useful to document drug effects on juvenile F. hepatica and
Klinik und Epidemiologie der Kryptosporidiose bei immunkompetenten Kindern (Publications)
longer than the period of diarrhoea (p = 0.02). Compared with control patients suffering from diarrhoea of other origin, respiratory symptoms were significantly (p = 0.02) more frequent in children with c
Antiprotozoal activity of <em>Achillea ptarmica</em> (Asteraceae) and its main alkamide constituents (Publications)
(sneezewort yarrow) was found to be active in vitro against Trypanosoma brucei rhodesiense (IC50 = 0.67 microg/mL) and Plasmodium falciparum (IC50 = 6.6 mug/mL). Bioassay guided fractionation led to the [...] 3.3 microg/mL), while 8,9-Z-dehydropellitorine was most active against T. b. rhodesiense (IC50 = 2.0 microg/mL). The activity of pure pellitorine against Plasmodium is higher than that of the crude extract
Quantitative structure: antiprotozoal activity relationships of sesquiterpene lactones (Publications)
activity, especially against T. brucei (e.g. helenalin and some of its esters with IC(50)-values of 0.05-0.1 microM, which is about 10 times lower than their cytotoxic activity). It was found that all in
Spatial distribution of<em> Falciparum</em> malaria infections in Zanzibar: implications for focal drug administration strategies targeting... (Publications)
from a population-based survey in 3 adjacent communities. Results.: Among 5278 persons screened, 13 (0.2%) were positive by RDT and 123 (2.3%) by PCR. PCR-positive individuals were scattered over the study [...] confidence interval, 2.8-19.9) for those living in the household of an RDT-positive individual and 1.64 (1.0-2.8; P = .06) for those living within 1000 m. Treating everyone within households of RDT-positive i
