Modification and optimization of the FECPAKG2 protocol for the detection and quantification of soil-transmitted helminth eggs in human stool (Publications)
present in the slurry of the sedimenter after overnight sedimentation (Ascaris: 95.7%, Trichuris: 89.8% and hookworm: 94.2% of the eggs). A minimum of 24 minutes were needed to ensure the accumulation of
Resource use, costs, and approval times for planning and preparing a randomized clinical trial before and after the implementation of the new Swiss... (Publications)
approval times from RECs and Swissmedic. RESULTS: The response rates of the investigator survey were 8.3% (19/228) for 2012 and 16.5% (47/285) in 2016. The median preparation cost of an RCT was USD 72,400
Pharmacokinetics of ascending doses of ivermectin in <em>Trichuris trichiura</em>-infected children aged 2-12 years (Publications)
t1/2 ( approximately 18 h), mean residence time (MRTINF) ( approximately 28 h) and V/F ( approximately 8 L/kg) were similar in all paediatric treatment arms. CONCLUSIONS: A positive association of AUC or Cmax
Fecal colonization with multidrug-resistant <em>E. coli</em> among healthy infants in rural Bangladesh (Publications)
the predominant (96%, n = 71) ESBL-gene followed by bla(TEM) (41%, n = 30) and bla(OXA-1) (11%, n = 8). A significant proportion (26.5%, n = 22) of 3GCr E. coli was pathogenic, comprising two types, en
Malaria standby emergency treatment (SBET) for travelers visiting malaria endemic areas: a systematic review and meta-analysis (Publications)
overall pooled prevalence of SBET use among the 26'403 travelers was 2.5% (95%CI 1.1%-4.3%; range 0.4%-10.8%). There was significant variation in the proportion of travelers carrying SBET medication (40%-100%)
Evaluation of emodepside in laboratory models of human intestinal nematode and schistosome infections (Publications)
against T. muris (ED50 = 1.2 mg/kg). Emodepside was moderately active on schistosomula in vitro (IC50 < 8 microM) 24 h post-drug incubation and its activity on adult S. mansoni and S. haematobium was low (IC50:
Genetic diversity of <em>Mycobacterium tuberculosis</em> strains circulating in Botswana (Publications)
into 44 clusters (2-46 isolates per cluster); giving a clustering rate of 76%. We identified 173 (37.8%) drug resistant isolates, 48 (10.5%) of these were multi-drug resistant. MIRU typing of the drug resistant
Preparation of sesquiterpene lactone-loaded PLA nanoparticles and evaluation of their antitrypanosomal activity (Publications)
vernolepin, and eucannabinolide, respectively. The NPs had encapsulation efficiencies of 94.6, 78.1, 76.8, 60.7, and 78.9% for alpha-santonin, arglabin, schkuhrin II, vernolepin, and eucannabinolide, respectively
Antiprotozoal aminosteroids from <em>Pachysandra terminalis</em> (Publications)
alkaloid (1), 7 new aminosteroids (2, 7, 16, 17, 18, 19, 20), along with 10 known aminosteroids (3-5, 8, 10-15) and 2 artifacts (6, 9) that were formed during the isolation process. The structures were elucidated
Factors contributing to retention in care and treatment adherence among people living with HIV returning to care in South-eastern Tanzania: a... (Publications)
Referral Hospital and Kibaoni Health Center.Five focus group discussions (FGDs) were conducted with 6-8 healthcare workers from Kibaoni, Mang'ula, Mkamba, Mgeta Health Center, and St. Francis Hospital. Data
