Drug susceptibility testing and mortality in patients treated for tuberculosis in high-burden countries: a multicentre cohort study (Publications)
with discordant results potentially leading to under-treatment. INTERPRETATION: Inaccurate drug susceptibility testing by comparison with a reference standard leads to under-treatment of drug-resistant [...] cohort study was done in Cote d'Ivoire, Democratic Republic of the Congo, Kenya, Nigeria, South Africa, Peru, and Thailand. We collected Mycobacterium tuberculosis isolates and clinical data from adult
Malaria exerts a massive burden on public health across the world, particularly in Africa. Huge strides have been made in recent decades in the treatment of malaria. However, to date, little data has been [...] metabolic differences in babies under 5kg. Infants under 5 kg can be affected by placental malaria, leading to poor birth outcomes, or contract malaria from the bite of an infected mosquito. The prevalence [...] tiny patients handle drugs differently due to the immaturity of their...
most vulnerable populations in Asia, Sub-Sahara Africa and the Americas. Leading institution in helminth drug development Swiss TPH is one of the leading institutions worldwide in discovering novel treatments
through individualised development plans, our in-house mentoring programme, access to university-level and language courses, and our dedicated in-house leadership programme. Ready to Make a Difference [...] brings together around 1,000 people from 96 countries. We are convinced that diverse perspectives lead to better science, stronger solutions and greater impact. Our Diversity, Equity and Inclusion (DEI)
are key to managing childhood pneumonia, especially severe/very severe pneumonia, which remains a leading cause of hospitalisation in lower/middle income countries. WHO recommends children with severe/very [...] aged 3 months to 10 years hospitalised with severe/very severe community-acquired pneumonia in South Africa, Uganda, Zambia and Zimbabwe by answering the following questions in a randomised trial using an [...] by optimising treatment for lower respiratory tract infections (LRTI) in...
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic... (Publications)
rotaviral enteritis (rotavirus) was the leading cause of under-5 deaths due to diarrhoea (146 000 deaths, 118 000-183 000) and pneumococcal pneumonia was the leading cause of under-5 deaths due to lower [...] caused the most YLLs throughout sub-Saharan Africa, with observed YLLs far exceeding expected YLLs for countries in which malaria or HIV/AIDS remained the leading causes of early death. INTERPRETATION: At [...] interval 61.4-61.9) in 1980 to 71.8 years (71.5-72.2) in 2015. Several...
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic... (Publications)
rotaviral enteritis (rotavirus) was the leading cause of under-5 deaths due to diarrhoea (146 000 deaths, 118 000-183 000) and pneumococcal pneumonia was the leading cause of under-5 deaths due to lower [...] caused the most YLLs throughout sub-Saharan Africa, with observed YLLs far exceeding expected YLLs for countries in which malaria or HIV/AIDS remained the leading causes of early death. INTERPRETATION: At [...] interval 61.4-61.9) in 1980 to 71.8 years (71.5-72.2) in 2015. Several...
countries in Africa and beyond, and will thus further expand the radius of potential beneficiaries. Implementation The project will be implemented from September 2017 to August 2022 under the lead of Mirko [...] health, the use of specific health impact assessments (HIA) is less common. Currently, no country in Africa actively promotes HIA, let alone regulates it. Existing evidence on the strengths and limitations [...] and any other large infrastructure developments – in the SDG 2030 Agenda...
Severe malaria and concomitant bacteraemia in children admitted to a rural Mozambican hospital (Publications)
life-threatening condition in many endemic African settings. In Mozambique, S. pneumoniae is the leading pathogen in this interaction, possibly as a consequence of the high HIV prevalence in the area. Measures [...] at reducing the burden of both those infections are urgently needed to reduce child mortality in Africa
A novel approach for measuring the burden of uncomplicated <em>Plasmodium falciparum</em> malaria: application to data from Zambia (Publications)
parasite prevalence surveys. The use of burden estimates that do not consider effects of treatment, leads to under-estimation of the impact of improvements in case management. Official estimates of burden [...] very likely massively underestimate the impact of the roll-out of ACT as first-line therapy across Africa. This paper proposes a novel approach for estimating burden of disease based on the point prevalence
