Improved inhibitors of trypanothione reductase by combination of motifs: synthesis, inhibitory potency, binding mode, and antiprotozoal activities (Publications)
respective parent compounds. The newly synthesized conjugates exhibit K(ic) values for TR as low as 0.51+/-0.1 muM and high selectivity for the parasitic enzyme over the related human glutathione reductase
Japanese encephalitis: defining risk incidence for travelers to endemic countries and vaccine prescribing from the UK and Switzerland (Publications)
Basel) and related to vaccine prescribing in UK and Swiss travelers. RESULTS: In 2004, an estimated 0.16% to 0.3% of UK and Swiss travelers were vaccinated against JE, with no surveillance reports of JE cases
Parental occupational exposure to extremely low frequency magnetic fields and childhood cancer: a German case-control study (Publications)
exposed preconceptionally at work to ELF-MFs had an increased risk of developing cancer. Cases aged 0-14 years were ascertained from the German Childhood Cancer Registry. Controls were selected from local [...] increased cancer risks in children whose fathers were occupationally exposed to magnetic fields above 0.2 microT. Additionally, there was no evidence for a risk increase at magnetic field levels exceeding
Residence near power lines and mortality from neurodegenerative diseases: longitudinal study of the Swiss population (Publications)
disease in persons living within 50 m of a 220-380 kV power line was 1.24 (95% confidence interval (CI): 0.80, 1.92) compared with persons who lived at a distance of 600 m or more. There was a dose-response [...] disease: Persons living at least 5 years within 50 m had an adjusted hazard ratio of 1.51 (95% CI: 0.91, 2.51), increasing to 1.78 (95% CI: 1.07, 2.96) with at least 10 years and to 2.00 (95% CI: 1.21
Association between annoyance and individuals' values of nitrogen dioxide in a European setting (Publications)
cities from 10 countries. Annoyance as a result of air pollution was self-reported on an 11-point scale (0, no disturbance at all; 10, intolerable disturbance). Demographic and socioeconomic factors, smoking [...] microg.m(-3) (from 10 in Umea, Sweden, to 57 in Barcelona, Spain). The mean of annoyance was 2.5 (from 0.7 in Reykjavik, Iceland, to 4.4 in Huelva, Spain). NO2 was associated with annoyance (ratio of the mean
Reduced cardiorespiratory fitness, low physical activity and an urban environment are independently associated with increased cardiovascular risk in... (Publications)
and nutritional parameters, media use, sleep duration, BMI and the neighbourhood environment (all p < 0.05). Children living in a rural environment were more physically active and had higher CRF values and [...] reduced HOMA-IR and metabolic risk scores compared with children living in an urban environment (all p < 0.05). These differences in cardiovascular risk factors persisted after adjustment for CRF, total PA and
Personal exposure assessment studies may suffer from exposure-relevant selection bias (Publications)
an increase of 100 cars per hour was associated with 14% less participation (odds ratio (OR): 0.861; 95% CI: 0.731, 1.007). Although in Helsinki, traffic volume was neither significantly related to participation
Leukaemia, brain tumours and exposure to extremely low frequency magnetic fields: cohort study of Swiss railway employees (Publications)
drivers was 1.43 (95% CI 0.74 to 2.77) compared with station masters. For myeloid leukaemia the HR of train drivers was 4.74 (95% CI 1.04 to 21.60) and for Hodgkin's disease 3.29 (95% CI 0.69 to 15.63). Lymphoid
Associations of peak shifts in age-prevalence for human malarias with bednet coverage (Publications)
a shift in age of peak prevalence from 4.7 (C = 0%) to 11.6 (C = 100%) years for Plasmodium falciparum, from 3.4 to 4.9 years for P. vivax and from 11.0 to 16.8 years for P. malariae. In small areas with
Cytochrome P450 6M2 from the malaria vector <em>Anopheles gambiae</em> metabolizes pyrethroids: sequential metabolism of deltamethrin revealed (Publications)
of K(M)=12+/-4muM and k(cat)=6+/-1 per min for permethrin (1:1 cis-trans) and K(M)=2.1+/-0.2muM and k(cat)=1.2+/-0.1 per min for deltamethrin. Mass spectrometry and NMR analysis identified 4'-hydroxy de
