Associations of peak shifts in age-prevalence for human malarias with bednet coverage (Publications)
a shift in age of peak prevalence from 4.7 (C = 0%) to 11.6 (C = 100%) years for Plasmodium falciparum, from 3.4 to 4.9 years for P. vivax and from 11.0 to 16.8 years for P. malariae. In small areas with
Cytochrome P450 6M2 from the malaria vector <em>Anopheles gambiae</em> metabolizes pyrethroids: sequential metabolism of deltamethrin revealed (Publications)
of K(M)=12+/-4muM and k(cat)=6+/-1 per min for permethrin (1:1 cis-trans) and K(M)=2.1+/-0.2muM and k(cat)=1.2+/-0.1 per min for deltamethrin. Mass spectrometry and NMR analysis identified 4'-hydroxy de
Acute phase proteins and white blood cell levels for prediction of infectious complications in status epilepticus (Publications)
three days after SE onset were significantly associated with the presence of infections (p=0.0012 for CRP, p=0.0137 for WBC). Levels of PCT were available for 31 patients and did not differ significantly
Inhibition of <em>Plasmodium falciparum</em> fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids (Publications)
microM), the more complex flavonoids (12-16) exhibited strong activity toward all three enzymes (IC50 0.5-8 microM). Isoflavonoids 26-28 showed moderate (IC50 7-30 microM) but selective activity against FabZ [...] gallic acid esters of catechins (32, 33, 37, 38), which are strong inhibitors of all three enzymes (IC50 0.2-1.1 microM). Kinetic analysis using luteolin (12) and (-)-catechin gallate (37) as model compounds
Risk factors of bovine tuberculosis in cattle in rural livestock production systems of Ethiopia (Publications)
of other livestock in the herd were statistically significant, with OR: 1.7, p-values of 0.03 and OR: 2, p = 0.05, respectively. Family members diagnosed with TB or showing clinical signs of extra-pulmonary
Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives (Publications)
dihydrochloride (55, IC50 = 3.0 nM) and seven other compounds exhibited IC50 values below 10 nM against T. b. rhodesiense in vitro. The 2-bromo-4,4'-diamidino analogue 19 (IC50 = 4.0 nM) and 12 other analogues
Design, synthesis, and <em>in vitro</em> cancer cell growth inhibition evaluation of troxianes installed in cyclic 2-enoate substructure (Publications)
leukemia (MV4-11) cell line (IC50 = 0.5 ?M). Compound 5o showed the highest growth factor inhibitory activity against a melanoma (LOX-IMVI) cancer cell line (GI50 = 1.0 ?M). A SAR study has confirmed the
Hepatitis A vaccine for immunosuppressed patients with rheumatoid arthritis: a prospective, open-label, multi-centre study (Publications)
Hepatitis A vaccine was administered to non-immune RA patients at 0 and 6 months. Hepatitis A virus (HAV) antibodies were assessed at 0, 1, 6, 7, 12, and 24 months with a quantitative Chemiluminescent
Comparative testing of a miniature diffusion size classifier to assess airbone ultrafine particles under field conditions (Publications)
y adjacent to a highway. Measurements with miniDiSC and P-TRAK correlated well (correlation of r = 0.84) but average particle numbers of the miniDiSC were 30%âeuro"60% higher. This difference was significantly [...] The correlation between theminiDiSC and the SMPSduring stationary measurements was very high (r = 0.98) although particle numbers from the miniDiSC were 30% lower. Differences between the three devices
Tetanus immunisation in geriatric patients with accidental wounds: how much is needed? (Publications)
(8/14) and between physicians' records and vaccination documents in 35.7% (5/14). Antitoxin titres > 0.15 IU/ ml were considered protective, giving a seroprevalence of 92.5%. Sensitivities and negative [...] after the single booster immunisation the median titre rose from 1.2 to 14.2 IU/ml, in group B from 0.9 to 5.3 IU/ml after the first, and to 9.6 IU/ml after the third tetanus toxoid dose (p
