Leisure-time vigorous physical activity is associated with better lung function: the prospective ECRHS study (Publications)
In adjusted models, active individuals at the first examination had higher FEV1 (43.6 mL (95% CI 12.0 to 75.1)) and FVC (53.9 mL (95% CI 17.8 to 89.9)) at both examinations than their non-active counterparts [...] FEV1 and FVC were higher among those who changed from inactive to active during the follow-up (38.0 mL (95% CI 15.8 to 60.3) and 54.2 mL (95% CI 25.1 to 83.3), respectively) and who were consistently
Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey (Publications)
to gases and fumes (RR 1.5, 95% CI 1.0 to 2.2) and pesticides (RR 2.2, 95% CI 1.1 to 3.8). The combined population attributable fraction for these exposures was 21.0%. INTERPRETATION: These results sub
Associations between dietary patterns and post-bronchodilation lung function in the SAPALDIA cohort (Publications)
(increase of 40 mL per SD, p < 0.001). Also for factor 3 ("high-carbohydrate diet"), we found a significant positive association with FEV1 (with an increase per SD of 36 mL, p = 0.006). CONCLUSIONS: The main
Multistage antiplasmodium activity of astemizole analogues and inhibition of hemozoin formation as a contributor to their mode of action (Publications)
to the compound's mode of action was interrogated. Ten of the seventeen derivatives showed IC50s < 0.1 microM against the chloroquine (CQ)-sensitive Plasmodium falciparum NF54 (PfNF54) strain while maintaining [...] PfK1, with most showing low likelihood of cross-resistance with CQ. Selected analogues (PfNF54- IC50 < 0.1 microM) were tested for cytotoxicity on CHO cells and found to be highly selective (selectivity index
Prevalence and determinants of undernutrition in schoolchildren in the Kilombero district, south-eastern Tanzania (Publications)
and obesity was 11.8%, 4.3%, 3.9%, 11.1%, and 2.0%, respectively. Overall, 1.5% of the children had malaria, as determined by rapid diagnostic tests, and 0.4% had severe anaemia. Univariate analysis indicated
Prevalence and determinants of undernutrition in schoolchildren in the Kilombero district, South-Eastern Tanzania (Publications)
and obesity was 11.8%, 4.3%, 3.9%, 11.1%, and 2.0%, respectively. Overall, 1.5% of the children had malaria, as determined by rapid diagnostic tests, and 0.4% had severe anaemia. Univariate analysis indicated
Safety and immunogenicity of radiation-attenuated PfSPZ vaccine in equatoguinean infants, children, and adults (Publications)
differences in solicited adverse events (AEs) between vaccinees and controls in any age group (P > /= 0.17). There were no significant differences between vaccinees and controls with respect to the rates [...] Development of antibodies to P. falciparum circumsporozoite protein occurred in 67/69 vaccinees (97%) and 0/15 controls. Median antibody levels were highest in infants and 1-5-year-olds and declined progressively
Laboratory-based efficacy evaluation of <em>Bacillus thuringiensis</em> var. <em>israelensis </em>and temephos larvicides against larvae of... (Publications)
larvae of invasive An. stephensi. METHODS: The diagnostic doses of two larvicides, temephos (0.25 ml/l) and Bti (0.05 mg/l) were tested in the laboratory against the immature stages (late third to early fourth
Physical activity, sedentary behaviour, weight status, and body composition among South African primary schoolchildren (Publications)
(ps < 0.001). Lower MVPA was associated with a higher likelihood of being overweight/obese, higher relative body fat, and lower relative fat-free mass, bone mass, muscle mass, and body water (ps < 0.001)
Care seeking and treatment of febrile children with and without danger signs of severe disease in northern Uganda: results from three household... (Publications)
compared with those without danger signs (adjusted odds ratio: 1.6, 95% confidence interval: 1.2-2.0; P < 0.01). In the total population studied, care seeking in the public sector was 26% and similar to care
