Investigation of indolglyoxamide and indolacetamide analogues of polyamines as antimalarial and antitrypanosomal agents (Publications)
was the most potent growth inhibitor of T. brucei (IC50 0.18 muM) identified in the study: it, however, also exhibited poor selectivity (L6 IC50 6.0 muM). There was no apparent correlation between antimalarial
Synthesis and biological evaluation of organoruthenium complexes with azole antifungal agents. First crystal structure of a tioconazole metal complex (Publications)
increasing number of ligands. However at 0.5 mM concentrations all tris-azole complexes statistically significantly reduced the radial growth rate, and also at 0.01 mM concentrations the monoazole complexes
Discovery of antischistosomal drug leads based on tetraazamacrocyclic derivatives and their metal complexes (Publications)
adult worms. Against NTS, all 5 compounds showed IC50 values comparable to that of standard drug PZQ (0.87 to 9.65 muM vs 2.20 muM for PZQ). Three of these, which are bisquinoline derivative of cyclen and [...] and Mn2+-complexes, showed micromolar IC50 values (1.62 muM, 1.34 muM and 4.12 muM, respectively vs 0.10 muM for PZQ) against adult worms. In vivo, the worm burden reductions were 12.3%, 88.4% and 74.8%
Varicella seroprevalence in individuals with a negative or unknown varicella history - results from a large travel clinic in Switzerland between 2008... (Publications)
40 years were significantly more often seronegative (9.5%) than those aged 40 years and above (6.0%, p = 0.049). Seropositivity was associated with nationality. The percentage of seropositives increased
The burden of leprosy in Cameroon: fifteen years into the post-elimination era (Publications)
achieved leprosy elimination in 2000, registering a prevalence rate of 0.94/10,000 population. The prevalence rate dropped further to reach 0.20/10,000 population (78% reduction) in 2014. Similarly, the new
Anti-trypanosomatid elemanolide sesquiterpene lactones from<em> Vernonia lasiopus </em>O. Hoffm (Publications)
dichloromethane extract was found to be particularly active against Trypanosoma brucei rhodesiense (IC50 = 0.17 microg/mL). Bioassay-guided chromatographic fractionation of the dichloromethane extract led to the [...] line). Vernolepin, the main component in the extract, was also the most potent with an IC50 value of 0.05 microg/mL against T.b. rhodesiense trypomastigotes. This compound showed a selectivity index of 14
An investment case to prevent the reintroduction of malaria in Sri Lanka (Publications)
economic cost of the malaria program in 2014 was estimated at U.S. dollars (USD) 0.57 per capita per year with a financial cost of USD0.37 per capita. The cost of potential malaria resurgence was, however, much
What physical activity surveillance needs: validity of a single-item questionnaire (Publications)
activity according to the single item and different accelerometer activity outcomes ranged from 0.40 to 0.54. Correlations were higher for women, younger individuals and participants from the French-speaking
Suspected cases of cholangiocarcinoma seen in reference hospitals in Lao People's Democratic Republic (Publications)
main characteristics of those identified. The majority were admitted to hospitals in the central (58.0%) and southern (29.6%) parts of Lao PDR. Abdominal pain (48.5%) and jaundice (14.2%) were the main symptoms [...] (97.4%) patients had dilated bile ducts; 40 (74.1%) had gallstone or intrahepatic stone, and 33 (12.0%) had a parasitologically confirmed O. viverrini infection. This study provides the first estimated
Absolute values of lung function explain the sex difference in breathlessness in the general population (Publications)
controlling for FEV1 % predicted (OR 2.33), but disappeared when controlling for absolute FEV1 (OR 0.89, 95% CI 0.69-1.14). Absolute FEV1 explained 98-100% of the sex difference adjusting for confounders. The
