Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis (Publications)
we observed that a 10 mug.m-3 increase in NO2 exposure was associated with lower levels of FEV1 (-14.0 mL, 95%CI -25.8- -2.1) and FVC (-14.9 mL, 95% CI -28.7- -1.1). An increase of 10 mug.m-3 in PM10, but [...] absorbance), was associated with a lower level of FEV1 (-44.6 mL, 95% CI -85.4- -3.8) and FVC (-59.0 mL, 95% CI -112.3- -5.6). The associations were particularly strong in obese persons. This study adds
Accelerated decline in lung function in smoking women with airway obstruction: SAPALDIA 2 cohort study (Publications)
quit before 2002 compared to persistent smokers (-6.4 vs -11.6 mL, p = 0.05) but this was not seen in men (-14.3 vs -8.8 mL p = 0.49). Smoking related decline was accelerated in men and women with airway
Integrating data from multiple time-location measurement methods for use in exposure assessment: the Multi-Ethnic Study of Atherosclerosis and Air... (Publications)
correlated with an individual's questionnaire report of typical behavior (Spearman's rho of 0.43 for home indoors and 0.39 for in-vehicle). Although questionnaire data about typical time-location patterns can
Use of antibody tools to provide serologic evidence of elimination of <em>Lymphatic filariasis</em> in the Gambia (Publications)
100 years. Overall, Bm14 prevalence was also low (1.5%, 95% CI 0.7-2.8%). Bm14 positivity was significantly associated with older age (P < 0.001). The low levels of antibody responses to Wb123 observed in
Antiprotozoal sesquiterpene lactones and other constituents from <em>Tarchonanthus camphoratus</em> and <em>Schkuhria pinnata</em> (Publications)
yloxy)costunolide (14) were the most active compounds found in this study, with IC50 values of 0.10 and 0.13 muM against Trypanosoma brucei rhodesiense trypomastigotes and selectivity indices of 20.5 and
Eau potable, assainissement et risque de maladies diarrhéiques dans la Communauté Urbaine de Nouakchott, Mauritanie (Publications)
water consumption and diarrhea (R = 0.429); collection of wastewater and occurrence of diarrhea ; existence of improved latrine and reduction of diarrheal risk (R = 0.402). DISCUSSION: Therefore, exposure
Leisure-time vigorous physical activity is associated with better lung function: the prospective ECRHS study (Publications)
In adjusted models, active individuals at the first examination had higher FEV1 (43.6 mL (95% CI 12.0 to 75.1)) and FVC (53.9 mL (95% CI 17.8 to 89.9)) at both examinations than their non-active counterparts [...] FEV1 and FVC were higher among those who changed from inactive to active during the follow-up (38.0 mL (95% CI 15.8 to 60.3) and 54.2 mL (95% CI 25.1 to 83.3), respectively) and who were consistently
Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey (Publications)
to gases and fumes (RR 1.5, 95% CI 1.0 to 2.2) and pesticides (RR 2.2, 95% CI 1.1 to 3.8). The combined population attributable fraction for these exposures was 21.0%. INTERPRETATION: These results sub
Associations between dietary patterns and post-bronchodilation lung function in the SAPALDIA cohort (Publications)
(increase of 40 mL per SD, p < 0.001). Also for factor 3 ("high-carbohydrate diet"), we found a significant positive association with FEV1 (with an increase per SD of 36 mL, p = 0.006). CONCLUSIONS: The main
Multistage antiplasmodium activity of astemizole analogues and inhibition of hemozoin formation as a contributor to their mode of action (Publications)
to the compound's mode of action was interrogated. Ten of the seventeen derivatives showed IC50s < 0.1 microM against the chloroquine (CQ)-sensitive Plasmodium falciparum NF54 (PfNF54) strain while maintaining [...] PfK1, with most showing low likelihood of cross-resistance with CQ. Selected analogues (PfNF54- IC50 < 0.1 microM) were tested for cytotoxicity on CHO cells and found to be highly selective (selectivity index
