Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3,... (Publications)
S/AS01 at months 0, 1, and 2 and a booster dose at month 20 (R3R group); three doses of RTS,S/AS01 and a dose of comparator vaccine at month 20 (R3C group); or a comparator vaccine at months 0, 1, 2, and 20 [...] a median of 48 months (IQR 39-50) and young infants for 38 months (34-41) after dose 1. From month 0 until study end, compared with 9585 episodes of clinical malaria that met the primary case definition [...] episode of severe malaria in the R3R group (32.2%, 13.7 to 46.9) and 169 in...
Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3,... (Publications)
S/AS01 at months 0, 1, and 2 and a booster dose at month 20 (R3R group); three doses of RTS,S/AS01 and a dose of comparator vaccine at month 20 (R3C group); or a comparator vaccine at months 0, 1, 2, and 20 [...] a median of 48 months (IQR 39-50) and young infants for 38 months (34-41) after dose 1. From month 0 until study end, compared with 9585 episodes of clinical malaria that met the primary case definition [...] episode of severe malaria in the R3R group (32.2%, 13.7 to 46.9) and 169 in...
Discovery and optimisation studies of antimalarial phenotypic hits (Publications)
vitro antimalarial activity of these compounds against P. falciparum K1 had EC50 values in the range of 0.09-29 muM, and generally good selectivity (typically > 100-fold) compared to a mammalian cell line (L6)
Antiparasitic chaiyaphumines from entomopathogenic <em>Xenorhabdus</em> sp. PB61.4 (Publications)
energy minimization. Chaiyaphumine A (1) showed good activity against Plasmodium falciparum (IC50 of 0.61 muM), the causative agent of malaria, and was active against other protozoal tropical disease causing
Longitudinal change of prebronchodilator spirometric obstruction and health outcomes: results from the SAPALDIA cohort (Publications)
obstruction was defined as an FEV(1)/FVC (forced expiratory volume in 1 s/forced vital capacity) ratio > /=0.70 at baseline and
Discovery and optimisation studies of antimalarial phenotypic hits (Publications)
vitro antimalarial activity of these compounds against P. falciparum K1 had EC50 values in the range of 0.09-29 muM, and generally good selectivity (typically > 100-fold) compared to a mammalian cell line (L6)
Antiparasitic chaiyaphumines from entomopathogenic <em>Xenorhabdus</em> sp. PB61.4 (Publications)
energy minimization. Chaiyaphumine A (1) showed good activity against Plasmodium falciparum (IC50 of 0.61 muM), the causative agent of malaria, and was active against other protozoal tropical disease causing
Longitudinal change of prebronchodilator spirometric obstruction and health outcomes: results from the SAPALDIA cohort (Publications)
obstruction was defined as an FEV(1)/FVC (forced expiratory volume in 1 s/forced vital capacity) ratio > /=0.70 at baseline and
The prevalence and risk of urinary tract infection in malnourished children: a systematic review and meta-analysis (Publications)
3294 malnourished children was 17% (95% CI, 13, 21%). Heterogeneity was high (I(2) = 87.6%; Tau(2) = 0.06) as studies varied in their sample size, degree of malnutrition, and study period. Multivariate [...] controls) was 2.34 (95% CI, 1.15, 3.34), with lower between-study heterogeneity (I(2) = 53.6%; Tau(2) = 0.47). CONCLUSIONS: UTI is more prevalent in malnourished children than in their well-nourished counterparts
