Seasonal malaria chemoprevention and the spread of <em>Plasmodium falciparum </em>quintuple-mutant parasites resistant to sulfadoxine-pyrimethamine: a... (Publications)
plus amodiaquine prevents millions of clinical malaria cases in children younger than 5 years in Africa's Sahel region. However, Plasmodium falciparum parasites partially resistant to sulfadoxine-pyrimethamine [...] the population, respectively. INTERPRETATION: SMC with sulfadoxine-pyrimethamine plus amodiaquine leads to a relatively slow spread of sulfadoxine-pyrimethamine-resistant quintuple mutants and remains effective
Potential impact of climatic factors on malaria in Rwanda between 2012 and 2021: a time-series analysis (Publications)
remains an important public health problem, particularly in sub-Saharan Africa. In Rwanda, where malaria ranks among the leading causes of mortality and morbidity, disease transmission is influenced by
Seasonal malaria chemoprevention and the spread of <em>Plasmodium falciparum </em>quintuple-mutant parasites resistant to sulfadoxine-pyrimethamine: a... (Publications)
plus amodiaquine prevents millions of clinical malaria cases in children younger than 5 years in Africa's Sahel region. However, Plasmodium falciparum parasites partially resistant to sulfadoxine-pyrimethamine [...] the population, respectively. INTERPRETATION: SMC with sulfadoxine-pyrimethamine plus amodiaquine leads to a relatively slow spread of sulfadoxine-pyrimethamine-resistant quintuple mutants and remains effective
Cost-effectiveness analysis of typhoid conjugate vaccines in an outbreak setting: a modeling study (Publications)
Several prolonged typhoid fever epidemics have been reported since 2010 throughout eastern and southern Africa, including Malawi, caused by multidrug-resistant Salmonella Typhi. The World Health Organization [...] already occurred. CONCLUSIONS: Countries for which the spread of antimicrobial resistance is likely to lead to outbreaks of typhoid fever should consider TCV introduction. Reactive vaccination can be a cos
Effects of climatic factors on diarrheal diseases among children below 5 years of age at national and subnational levels in Nepal: an ecological study (Publications)
INTRODUCTION: The incidence of diarrhea, a leading cause of morbidity and mortality in low-income countries such as Nepal, is temperature-sensitive, suggesting it could be associated with climate change [...] precipitation, the incidence of water and food-borne diseases are increasing, particularly in sub-Saharan Africa and South Asia. This national-level ecological study was undertaken to provide evidence linking weather
Primary cultivation: factors affecting contamination and <em>Mycobacterium ulcerans</em> growth after long turnover time of clinical specimens (Publications)
ulcerans remains an essential tool. Since for most of the remote Buruli ulcer endemic regions of Africa cultivation laboratories are not easily accessible, samples from lesions often have to be stored [...] medium yielded the best results. We further found that, ten extra days between sampling and inoculation lead to a relative decrease in the isolation rate of M. ulcerans by nearly 20%. Finally, collection and
Can action research strengthen district health management and improve health workforce performance? A research protocol (Publications)
INTRODUCTION: The single biggest barrier for countries in sub-Saharan Africa (SSA) to scale up the necessary health services for addressing the three health-related Millennium Development Goals and achieving [...] With the support of the country research teams, the district health management teams (DHMTs) will lead on planning, implementation, observation, reflection and redefinition of the activities in the study
Estimating the burden of scrub typhus: a systematic review (Publications)
typhus since the year 2000. FINDINGS: In prospective fever studies from Asia, scrub typhus is a leading cause of treatable non-malarial febrile illness. Sero-epidemiological data also suggest that Orientia [...] wider distribution of scrub typhus beyond Asia is likely, based on reports from South America and Africa. Unfortunately, the quality and quantity of the available data on scrub typhus epidemiology is currently
qualitative research methods at postgraduate and graduate level at Swiss TPH and supervises students. She leads the Psychosocial-Medicine Internship on behalf of the Medical Faculty at the University Basel, responsible [...] has worked extensively in Tanzania and other African countries (Senegal, Kenya, Rwanda, Southern Africa, Malawi, Zimbabwe, Ethiopia, Comores, Egypt), Asia and Central Asia (India, Myanmar, Nepal, Thailand [...] and Eastern Europe (Kosovo, Moldova). Current mandates July...
topics related to One Health and the fight against parasitic worm diseases. Swiss TPH acts as a “leading house” for both the CSRS and the IHI. Centre de Support en Santé Internationale (CSSI), Chad Since the [...] Harvard T.H. Chan School of Public Health, US Helmholtz Centre for Infection Research, DE Hes-so Leading House (MENA), CH Ifakara Health Institute (IHI), TZ Imperial College London, UK Innovative Vector Control [...] Over the years, it has become one of the most renowned research and...
