<em>In vitro </em>and <em>in vivo</em> drug interaction study of two lead combinations, oxantel pamoate plus albendazole and albendazole plus... (Publications)
curve (AUC) and maximal plasma concentration (Cmax) were augmented 3.5- and 2.8-fold, respectively (P = 0.02 for both) when coadministered with albendazole compared to mebendazole alone. Albendazole sulfone [...] albendazole alone. Oxantel pamoate could not be quantified, translating to a bioavailability below 0.025% in rats. Elevated plasma levels of albendazole sulfoxide, albendazole sulfone, and mebendazole
Dynamics of freshwater snails and <em>Schistosoma</em> infection prevalence in schoolchildren during the construction and operation of a multipurpose... (Publications)
were shedding cercariae. The prevalence of S. mansoni among adults in the study area was low (0.4% in 2007 and 0.3% in 2009), whereas the prevalence of S. haematobium declined from 13.9% to 2.9% in this two-year
Understanding resilience of female adolescents towards teenage pregnancy: a cross-sectional survey in Dar es Salaam, Tanzania (Publications)
never-pregnant girls [OR = 1.80, 95% CI = 1.06 to 3.07, p = 0.029], pregnant adolescents and young mothers [OR = 3.33, 95% CI = 1.15 to 9.60, p = 0.026]. CONCLUSIONS: The reproductive resilience framework
Small-scale field evaluation of push-pull system against early- and outdoor-biting malaria mosquitoes in an area of high pyrethroid resistance in... (Publications)
y. However, the reductions were marginal and insignificant for An. funestus (12.2%; p> 0.05) and Culex (5%; p> 0.05). Highest protection against all species occurred before 2200hrs. There was no significant
Potential factors influencing lymphatic filariasis transmission in “hotspot” and “control” areas in Ghana: the importance of vectors (Publications)
Mpohor district (F = 16.09, P = 0.002). There was no significant difference between the numbers of mosquitoes collected in Kassena Nankana West and Bongo districts (F = 2.16, P = 0.185). Mansonia species were
Evaluation of household coverage with long-lasting insecticidal nets in central Côte d'Ivoire (Publications)
8% (95% CI: 58.7-68.8). Household LLIN access was 37.6% (95% CI: 33.2-42.0) based on 1 LLIN per 2 persons and 37.1% (95% CI: 33.0-41.2) based on 1 net per sleeping unit. Population LLIN access based on
Estimating the hole surface area of insecticide-treated nets using image analysis, manual hole counting and exact hole measurements (Publications)
ratio of the hole surface area from image analysis to the ground truth of 0.70, and the 95% limits of agreement ranging from 0.35 to 1.38. Manual hole counting underestimated the hole surface area compared
Evaluation of bio-efficacy of field-aged novel long-lasting insecticidal nets (PBO, chlorfenapyr or pyriproxyfen combined with pyrethroid) against... (Publications)
30 months, with 50 nets sampled at 36 months. WHO cone bioassays and tunnel tests were performed at 0, 12, 24, 30 and 36 months. Both susceptible An. gambiae (s.s.) Kisumu strain and resistant An. gambiae [...] (24 h) ranged between 84% and 33% in tunnel tests with superior efficacy compared to Interceptor at 0, 24 and 36 months. Sterility effects in Royal Guard were higher when these nets were new and at six
Prevalence, years lived with disability, and trends in anaemia burden by severity and cause, 1990-2021: findings from the Global Burden of Disease... (Publications)
and countries in sub-Saharan Africa and south Asia being particularly affected. Anaemia caused 52.0 million (35.1-75.1) YLDs in 2021, and the YLD rate due to anaemia declined with increasing Socio-demographic [...] per 100 000 population: 422.4 [95% UI 286.1-612.9]), haemoglobinopathies and haemolytic anaemias (89.0 [58.2-123.7]), and other neglected tropical diseases (36.3 [24.4-52.8]), collectively accounting for
Antibiotic use and consumption among medical patients of two hospitals in Sierra Leone: a descriptive report (Publications)
evaluated in this study was 48.6 years. The majority were women (241, 51.7%) and treated at MGH (245, 52.0%). Clinical diagnosis of bacterial infection was made in only 180 (38.5%) patients. Regardless of the [...] (277, 34.1%). The ACCESS and WATCH antibiotics accounted for 18.9 DDDs per 100 bed-days (28.2%) and 48.0 DDDs per 100 bed-days (71.7%), respectively. None of the patients were prescribed a RESERVE antibiotics
