Is diabetes a risk factor for a severe clinical presentation of dengue? Review and meta-analysis (Publications)
prevalence of both dengue and diabetes justifies further studies. At this point, confirmation of dengue infection as early as possible in diabetes patients with fever if living in dengue endemic regions seems [...] clinical presentation of dengue. METHODOLOGY/FINDINGS: A systematic literature review was conducted using the MEDLINE database to access any relevant association between dengue and diabetes. Five case-control [...] presentation of dengue (OR 1.75; 95% CI: 1.08-2.84, p = 0.022)....
Community effectiveness of pyriproxyfen as a dengue vector control method: a systematic review (Publications)
measured the reduction in human dengue cases, with inconclusive results. CONCLUSIONS: Although pyriproxyfen is highly effective in controlling the immature stages of dengue transmitting mosquitoes, and-to [...] BACKGROUND: Vector control is the only widely utilised method for primary prevention and control of dengue. The use of pyriproxyfen may be promising, and autodissemination approach may reach hard to reach [...] a vector control method for reducing Ae. aegypti and Ae. albopictus...
Dengue data and surveillance in Tanzania: a systematic literature review (Publications)
OBJECTIVE: Although there is evidence that dengue virus is circulating in Tanzania, the country lacks a dengue surveillance system. Consequently, the true estimate of dengue seroprevalence, as well as the incidence [...] estimated seroprevalence of past dengue infection in Tanzania ranged from 50.6% in a health facility-based study to 11% in a population-based study. Acute confirmed infections of dengue were estimated to be as [...] evident that dengue needs to become part of regular disease...
Development of dengue virus serotype-specific NS1 capture assays for the rapid and highly sensitive identification of the infecting serotype in human... (Publications)
Dengue fever can be caused by one of four distinct dengue virus (DENV) serotypes that cocirculate in many parts of the world. Point of care serotype-specific nonstructural protein-1 (NS1) capture assays [...] sensitive and specific NS1 serotyping ELISAs (st-ELISAs) for the four serotypes. st-ELISA testing of 41 dengue patient sera showed a 100% concordance with the serotype determined by serotype-specific reverse [...] distinguish protective versus enhancing Ab responses for risk assessment for...
Dengue fever in Dar es Salaam, Tanzania: clinical features and outcome in populations of black and non-black racial category (Publications)
BACKGROUND: Although the incidence of dengue across Africa is high, severe dengue is reported infrequently. We describe the clinical features and the outcome of dengue according to raceduring an outbreak [...] coinfection, secondary dengue and duration of symptoms at inclusion. The independent association between demographic and comorbidities characteristics of the patients and severe dengue was evaluated by mu [...] presented with severe dengue. Non-black race (adjusted OR 3.9; 95% CI 1.3-12)...
Diagnosis of murine typhus by serology in Peninsular Malaysia: a case report where rickettsial illnesses, leptospirosis and dengue co-circulate (Publications)
Murine typhus is a rarely diagnosed cause of acute febrile illness in Malaysia, and its true disease burden is unknown. We report a case of an acute murine typhus infection in a patient living in a sm
A prospective study on the impact and out-of-pocket costs of dengue illness in international travelers (Publications)
emerging and reemerging infectious diseases, such as dengue. This exploratory study aims to investigate the impact and out-of-pocket costs of dengue illness among travelers. We conducted a prospective study [...] direct and indirect costs because of dengue-related illness. This study is the first to date to investigate the impact and out-of-pocket costs of travel-related dengue illness from the patient's perspective [...] Although the costs of dengue illness to patients and households have...
Evolution of subgenomic RNA shapes dengue virus adaptation and epidemiological fitness (Publications)
Changes in dengue virus (DENV) genome affect viral fitness both clinically and epidemiologically. Even in the 3' untranslated region (3' UTR), mutations could affect subgenomic flaviviral RNA (sfRNA)
Scalable camera traps for measuring the attractiveness of sugar baits for controlling malaria and dengue vectors (Publications)
BACKGROUND: Attractive targeted sugar baits (ATSBs) are promising new interventions that can complement existing vector control tools. However, reproducible and quantitative information on the level o
