Incidence and types of illness when traveling to the tropics: a prospective controlled study of children and their parents (Publications)
exposing them to infectious agents and tropical diseases not encountered at home. We studied 157 children (0-16 years) and their adult relatives traveling to the tropics, who attended a pretravel clinic and were
Performance of the Xpert((R)) MTB/RIF assay in an active case-finding strategy: a pilot study from Tanzania [Short communication] (Publications)
microscopy was 60% (95%CI 14.7-94.7), Xpert MTB/RIF achieved a sensitivity of 100% (95%CI 47.81-100.0). All culture-confirmed cases tested positive by Xpert MTB/RIF on the first submitted sample, suggesting
Successful treatment of acute mountain sickness with dexamethasone (Publications)
eight of 17 patients became totally asymptomatic. Mean arterial oxygen saturation rose from 75.5% to 82.0%, and there was a small increase in standard spirometric measurements. In the placebo group none of
Triterpenoids with rare carbon skeletons from <em>Salvia hydrangea</em>: antiprotozoal activity and absolute configurations (Publications)
determined. Compounds 1 and 2 showed in vitro antiplasmodial activity, with IC(50) values of 1.43 and 0.18 muM and selectivity indices (SI) of 86.2 and 69.6, respectively. IC(50) values against T. brucei
Antiprotozoal activities of heterocyclic-substituted xanthones from the marine-derived fungus <em>Chaetomium</em> sp (Publications)
measurements. Compound 2 showed selective activity against Plasmodium falciparum with an IC50 value of 0.5 microg/mL without being cytotoxic toward cultured eukaryotic cells. Compound 3 displayed a moderate
Comparative antiplasmodial, leishmanicidal and antitrypanosomal activities of several biflavonoids (Publications)
brucei rhodesiense bloodstream forms. Lanaroflavone showed the highest antiplasmodial activity (IC(50) = 0.48 microM), isoginkgetin was the most active leishmanicidal compound (IC(50) = 1.9 microM), whereas
Imidazolopiperazines: hit to lead optimization of new antimalarial agents (Publications)
after administration of 100 mg/kg single oral dose and prolonged mice survival by an average of 17.0 days. The lead compounds were also well-tolerated in the preliminary in vitro toxicity studies and
Novel 3-nitro-1H-1,2,4-triazole-based amides and sulfonamides as potential antitrypanosomal agents (Publications)
drug benznidazole, tested in parallel. In addition, nine nitrotriazoles which were moderately active (0.5 muM
Use of sap flow measurements to validate stomatal functions for mature beech (<em>Fagus sylvatica</em>) in view of ozone uptake calculations (Publications)
Switzerland. A canopy conductance was calculated from sap flow velocity and normalized to values between 0 and 1. It represents mainly stomatal conductance as the boundary layer resistance in forests is usually
Low efficacy of albendazole against <em>Trichuris trichiura</em> infection in schoolchildren from Port Elizabeth, South Africa (Publications)
[CR] 97.2%; egg reduction rate [ERR] 94.3%), it lacked efficacy against T. trichiura (CR 1.1%; ERR 46.0%). CONCLUSIONS: Our study confirms low efficacy of single dose albendazole against T. trichiura. There
