Is fever a good sign for clinical malaria in surveys of endemic communities? (Publications)
prevalences of malaria-attributable morbidity of 9.8% in infants, 1.3% in children 1-4 years of age, and 0.6% in those 5-9 years of age were estimated. No illness was considered to be due to malaria in older
Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues (Publications)
4-b]indole (9), or 2-methyl-beta-carboline, showed the best in vitro activity, with an IC(50) value of 0.45 microM against P. falciparum K1, without apparent cytotoxicity against L6 cells (SI> 1000). However
Evaluation of ethnobotanically selected Benin medicinal plants for their in vitro antiplasmodial activity (Publications)
sensitive 3D7 strain was the methanolic extract of Croton lobatus aerial part, with an IC50 value of 0.38 microg/ml. The best inhibition of the growth of Plasmodium falciparum resistant K1 strain was observed
Growth losses in Swiss forests caused by ozone: epidemiological data analysis of stem increment of <em>Fagus sylvatica L.</em> and <em>Picea... (Publications)
estimates amount to 19.5% growth reduction for deciduous forests, 6.6% for coniferous forests and 11.0% for all forested areas based on annual ozone stomatal uptake during the time period 1991-2011
Investigating the spill-over hypothesis: analysis of the association between local inflammatory markers in sputum and systemic inflammatory mediators... (Publications)
inflammatory mediators in sputum and plasma, correlation coefficients were rather low ranging from r> /=-0.20 to r
Children's personal exposure measurements to extremely low frequency magnetic fields in Italy (Publications)
Although epidemiological studies claimed an evidence of a possible association between ELF-MF above 0.4 muT and childhood leukemia, biological mechanisms able to support a causal relationship between ELF-MF
<em>In vitro</em> activity of anti-malarial ozonides against an artemisinin-resistant isolate (Publications)
mutation R539T (Cam3.IR539T). METHODS: The previously described in vitro ring-stage survival assay (RSA0-3h) was employed and a simplified variation of the original protocol was developed. RESULTS: At the
High blood pressure: prevalence and adherence to guidelines in a population-based cohort (Publications)
High blood pressure was found in 34.9% of subjects, 49.1% of whom were unaware of this condition; 30.0% had doctor-diagnosed hypertension and, although 82.1% of these received drug treatments, in only 40
Investigating sulfoxide-to-sulfone conversion as a prodrug strategy for a phosphatidylinositol 4-kinas inhibitor in a humanized mouse model of malaria (Publications)
which would lead to improved drug exposure on oral dosing. Both compounds had similar efficacy (ED90 0.1 mg.kg(-1)) across a quadruple-dose regimen. Pharmacokinetic profiling revealed rapid sulfoxide clearance
Antiprotozoal isoprenoids from <em>Salvia hydrangea</em> (Publications)
assessed in rat myoblast L6 cells. Perovskone C (2) exhibited good activity against P. falciparum (IC50 0.6 muM) and a selectivity index of 62.2.
