Laboratory findings, compassionate use of favipiravir, and outcome in patients with Ebola virus disease, Guinea, 2015 - a retrospective observational... (Publications)
favipiravir-treated patients was lower than in untreated patients (31/73 [42.5%] vs. 52/90 [57.8%], p = 0.053 in univariate analysis). In the multivariate regression analysis, higher Ct value and younger age
Machine learning-based lifetime breast cancer risk reclassification compared with the BOADICEA model: impact on screening recommendations (Publications)
based on the Swiss Surveillance Protocol. RESULTS: The predictive accuracy of ML-based algorithms (0.843
Hyperendemicity, heterogeneity and spatial overlap of leprosy and cutaneous leishmaniasis in the southern Amazon region of Brazil (Publications)
distribution heterogeneity. Scan statistics demonstrated overlap of high-risk clusters for leprosy (RR = 2.0; p
Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase (Publications)
reported inhibitors. The most active compound reported here against the P. falciparum enzyme had a K(i) of 0.2 microM. Molecular modeling studies provided a good rationale for the observed activities. Preliminary
New algorithm for managing childhood illness using mobile technology (ALMANACH): a controlled non-inferiority study on clinical outcome and antibiotic... (Publications)
Tanzania. Primary outcomes were proportion of children cured at day 7 and who received antibiotics on day 0. RESULTS: 130/842 (154%) in ALMANACH and 241/623 (387%) in control arm were diagnosed with an infection
The impact of indoor residual spraying with malathion on malaria in refugee camps in eastern Sudan (Publications)
the most common mosquito collected. The mean human blood index of 242 mosquitoes from eight camps was 0.51. Only two of 1040 mosquitoes examined harboured sporozoites. Blood samples of 83 putative malaria
Treatment of acute uncomplicated <em>Falciparum</em> malaria with artemether-lumefantrine in nonimmune populations: a safety, efficacy, and... (Publications)
with the six-dose regimen of artemether-lumefantrine. The parasitologic cure rate at 28 days was 96.0% for the per protocol population (119/124 patients). Median times to parasite clearance and fever clearance
Current status of schistosomiasis and soil-transmitted helminthiasis in Beyla and Macenta Prefectures, Forest Guinea (Publications)
intensity of infection was 66.2% and 462.4 eggs per gram of faeces (epg) for Schistosoma mansoni, 21.0% and 17.8 eggs per 10ml of urine for S. haematobium, 51.2% and 507.5 epg for hookworm, 8.1% and 89.1
Discovery and preliminary structure-activity relationship analysis of 1,14-sperminediphenylacetamides as potent and selective antimalarial lead... (Publications)
(orthidine F, 1) as being a non-toxic, moderate growth inhibitor of Plasmodium falciparum (IC(50) 0.89?M). Preliminary structure-activity relationship investigation identified essentiality of the spermine
<em>In vitro</em> screening of traditional South African malaria remedies against <em>Trypanosoma brucei rhodesiense</em>, <em>Trypanosoma cruzi,... (Publications)
determined. Amongst the most notable results are the activities of AGATHOSMA APICULATA (IC (50) of 0.3 microg/mL) against PLASMODIUM FALCIPARUM, as well as SALVIA REPENS and MAYTENUS UNDATA against LEISHMANIA
