Investigating sulfoxide-to-sulfone conversion as a prodrug strategy for a phosphatidylinositol 4-kinas inhibitor in a humanized mouse model of malaria (Publications)
which would lead to improved drug exposure on oral dosing. Both compounds had similar efficacy (ED90 0.1 mg.kg(-1)) across a quadruple-dose regimen. Pharmacokinetic profiling revealed rapid sulfoxide clearance
Antiprotozoal isoprenoids from <em>Salvia hydrangea</em> (Publications)
assessed in rat myoblast L6 cells. Perovskone C (2) exhibited good activity against P. falciparum (IC50 0.6 muM) and a selectivity index of 62.2.
Laboratory findings, compassionate use of favipiravir, and outcome in patients with Ebola virus disease, Guinea, 2015 - a retrospective observational... (Publications)
favipiravir-treated patients was lower than in untreated patients (31/73 [42.5%] vs. 52/90 [57.8%], p = 0.053 in univariate analysis). In the multivariate regression analysis, higher Ct value and younger age
Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188... (Publications)
3 years (65.0-65.6) in 1990 to 71.5 years (71.0-71.9) in 2013, HALE at birth rose by 5.4 years (4.9-5.8), from 56.9 years (54.5-59.1) to 62.3 years (59.7-64.8), total DALYs fell by 3.6% (0.3-7.4), and
Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188... (Publications)
3 years (65.0-65.6) in 1990 to 71.5 years (71.0-71.9) in 2013, HALE at birth rose by 5.4 years (4.9-5.8), from 56.9 years (54.5-59.1) to 62.3 years (59.7-64.8), total DALYs fell by 3.6% (0.3-7.4), and
Glycaemic control among patients with type 2 diabetes followed in a rural African primary care setting - a reality check in the Democratic Republic of... (Publications)
319 diabetic patients (212 men, 107 women) were enrolled. The target threshold of HbA1c level at 7.0% or below was met by 17.8% (19/107) of female and 12.3% (26/212) of male patients. The fasting plasma
Efficient oxidative dearomatisations of substituted phenols using hypervalent iodine (iii) reagents and antiprotozoal evaluation of the resulting... (Publications)
naphthoquinone 5c was the most active and selective molecule against T. brucei rhodesiense (IC50 = 0.08 muM, SI = 275). Furthermore, the antiprotozoal assays revealed no specific effects. In addition,
Prevalence of four enteropathogens in the faeces of young diarrhoeic dairy calves in Switzerland (Publications)
status of each calf was evaluated. The prevalences of C parvum, rotavirus, BCV and E coli k99 were 55.0 per cent, 58.7 per cent, 7.8 per cent and 5.5 per cent, respectively. The proportions of herds positive
New fluorescence markers to distinguish co-infecting <em>Trypanosoma brucei</em> strains in experimental multiple infections (Publications)
counts by FACS were virtually identical to counts by traditional microscopy (n=75, Spearman's rho: 0.91, p
Shoot growth of mature Fagus sylvatica and Picea abies in relation to ozone (Publications)
between ozone and shoot growth was observed which corresponded to a 7.4% growth reduction between 0 and 10 ppm h AOT40 (accumulated ozone over threshold 40). This is in the same order of magnitude as
