A malaria risk map of Kinshasa, Democratic Republic of Congo (Publications)
surveys, malaria prevalence was 14.1 % and 26.8 % in Selembao (peri-urban), in the 2009 dry season and 2011 rainy season respectively, and it was 1.0 % and 0.8 % in Ngiri Ngiri (urban). History of fever during [...] during the preceding two weeks was 13.2 % (12.5-14.3) and 22.3 % (20.8-23.4) in 2009 and 2011. Household ownership of at least one insecticide-treated net (ITN) was 78.7 % (77.4-80.0) and 65.0 % (63.7-66 [...] 7-66.3) at both time points, while use was 57.7 % (56.0-59.9) and 45.0 %...
Safety, immunogenicity and efficacy of PfSPZ vaccine against malaria in infants in western Kenya: a double-blind, randomized, placebo-controlled phase... (Publications)
10(5), 9.0 x 10(5) or 1.8 x 10(6) PfSPZ Vaccine or saline three times at 8-week intervals. The vaccine was well tolerated; 52 (20.6%) children in the vaccine groups and 20 (23.8%) in the placebo group [...] the study). VE against clinical malaria 3 months after the last dose in the highest-dose group was 45.8% (P = 0.027), an exploratory end point. There was a dose-dependent increase in antibody responses that
An autoencoder and artificial neural network-based method to estimate parity status of wild mosquitoes from near-infrared spectra (Publications)
9+/-2.8 (N = 274), 68.7+/-4.8 (N = 43), 80.3+/-2.0 (N = 48), and 75.7+/-2.5 (N = 91), respectively. With the autoencoder, ANN models tested on out-of-sample data achieved 97.1+/-2.2% (N = 274), 89.8 +/- [...] +/- 1.7% (N = 43), 93.3+/-1.2% (N = 48), and 92.7+/-1.8% (N = 91) accuracies for Minepa-ARA, Muleba-GA, Burkina-GA, and Muleba-Burkina-GA, respectively. These results show that a combination of an autoencoder
Marine natural products from the Turkish sponge <em>Agelas oroides</em> that inhibit the enoyl reductases from <em>Plasmodium falciparum</em>,<em>... (Publications)
of a 1:2 mixture of (5Z,9Z)-5,9-tricosadienoic (7) and (5Z,9Z)-5,9-tetracosadienoic (8) acids, and FAMB composed of 8, (5Z,9Z)-5,9-pentacosadienoic (9) and (5Z,9Z)-5,9-hexacosadienoic (10) acids in app [...] microg/ml). Enzyme kinetic studies showed 4a to be an uncompetitive PfFabI inhibitor (K(i): 0.4+/-0.2 and 0.8+/-0.2 microM with respect to substrate and cofactor). In addition, FAMA and FAMD (mainly consisting [...] methyl-branched fatty acids) inhibited FabI of Mycobacterium tuberculosis...
A malaria risk map of Kinshasa, Democratic Republic of Congo (Publications)
surveys, malaria prevalence was 14.1 % and 26.8 % in Selembao (peri-urban), in the 2009 dry season and 2011 rainy season respectively, and it was 1.0 % and 0.8 % in Ngiri Ngiri (urban). History of fever during [...] during the preceding two weeks was 13.2 % (12.5-14.3) and 22.3 % (20.8-23.4) in 2009 and 2011. Household ownership of at least one insecticide-treated net (ITN) was 78.7 % (77.4-80.0) and 65.0 % (63.7-66 [...] 7-66.3) at both time points, while use was 57.7 % (56.0-59.9) and 45.0 %...
Discovery of ircinianin lactones B and C: two new cyclic sesterterpenes from the marine sponge <em>Ircinia wistarii</em> (Publications)
lactone C (7 and 8), together with five known entities from the ircinianin compound family (1, 3–6) were isolated from the marine sponge Ircinia wistarii. Ircinianin lactones B and C (7 and 8) represent new
Abnormal blood glucose concentrations on admission to a rural Kenyan district hospital: prevalence and outcome (Publications)
was 20.2% compared to 3.8% in normoglycaemic children (p < 0.001). The brunt of mortality in hypoglycaemic children was borne by those who were severely ill or malnourished (31.8%) as opposed to those who
Randomized double-blind controlled Phase I/IIa trial to assess the efficacy of malaria vaccine PfCS102 to protect against challenge with <em>P.... (Publications)
using 5 infected mosquitoes. All vaccinees developed antibodies against PfCS102 versus none control. 8/8 vaccinees and 6/6 controls challenged developed malaria parasitaemia. The duration from infection to
Current status of schistosomiasis and soil-transmitted helminthiasis in Beyla and Macenta Prefectures, Forest Guinea (Publications)
per gram of faeces (epg) for Schistosoma mansoni, 21.0% and 17.8 eggs per 10ml of urine for S. haematobium, 51.2% and 507.5 epg for hookworm, 8.1% and 89.1 epg for Ascaris lumbricoides and 2.4% and 16.7 epg
Presence of nonhemolytic pneumolysin in serotypes of <em>Streptococcus pneumoniae</em> associated with disease outbreaks (Publications)
isolates is also present in a number of pneumococcal isolates of serotype 8 that belong to the ST53 lineage. Serotype 1 and 8 pneumococci are known to be associated with outbreaks of invasive disease.
