Validation of a point-of-care circulating cathodic antigen urine cassette test for <em>Schistosoma mansoni</em> diagnosis in the Sahel, and potential... (Publications)
POC-CCA urine cassette tests revealed a Schistosoma mansoni prevalence of 6.9%, compared with only 0.5% by stool microscopy. Four pregnant women with negative coprology had positive POC-CCA. This observation
The locus <em>C11orf30</em> increases susceptibility to poly-sensitization (Publications)
C11orf30-rs2155219, doubles the risk of poly-sensitization (specific IgE/4 allergens: OR = 1.81, 95% CI 0.80-4.24; skin prick test/4+ allergens: OR = 2.27, 95% CI 1.34-3.95). The association of rs2155219 with
Repurposing a library of human cathepsin L ligands: identification of macrocyclic lactams as potent rhodesain and <em>trypanosoma brucei... (Publications)
rats determined. When tested in vivo in acute HAT model, the compounds permitted up to 16.25 (vs 13.0 for untreated controls) mean days of survival.
Similar prevalence of <em>Plasmodium falciparum</em> and Non-<em>P. falciparum</em> malaria infections among schoolchildren, Tanzania (Publications)
Among 3,456 schoolchildren, 22% had P. falciparum, 24% had P. ovale spp., 4% had P. malariae, and 0.3% had P. vivax infections. Most (91%) schoolchildren with P. ovale infections had low parasite densities;
Expanding the activity profile of pyrido[1,2-a]benzimidazoles: synthesis and evaluation of novel n(1)-1-phenylethanamine derivatives against... (Publications)
Here, we report a novel series of antischistosomal PBIs with potent in vitro activity (IC50 values of 0.08-1.43 muM) against Schistosoma mansoni newly transformed schistosomula and adult worms. Moreover,
Synthesis, <em>in vitro</em> antiprotozoal activity, molecular docking and molecular dynamics studies of some new monocationic guanidinobenzimidazoles (Publications)
throughout 200 ns time. Root mean square deviation (RMSD) values of the ligands remained stable below 0.25 mm and root mean square fluctuation (RMSF) values of the active site residues with which it interacted
The "double burden of malnutrition" in the Amazon: dietary change and drastic increases in obesity and anemia over 40 years among the Awajun (Publications)
obesity were also substantially higher in 2013 compared to the 1970s (23% vs 6% for anemia and 30% vs. 0% for obesity) indicating a DBM has emerged. Examining the predictors of hemoglobin levels and body mass
The discovery of novel antitrypanosomal 4-phenyl-6-(pyridin-3-yl)pyrimidines (Publications)
compound 13, the 4-(2-methoxyphenyl)-6-(pyridine-3-yl)pyrimidin-2-amine demonstrating an IC50 value of 0.38 muM and a promising off-target ADME-Tox profile in vitro. In silico molecular target investigations
Complement factor D, albumin, and immunoglobulin G anti-band 3 protein antibodies mimic serum in promoting rosetting of malaria-infected red blood... (Publications)
Complement factor D alone induced 30 to 40% of de novo rosetting. Its effect was additive to that of 0.5 mg/ml albumin and to that of 15 ng/ml of naturally occurring antibodies to the anion transport protein
Changing patterns of soil-transmitted helminthiases in Zanzibar in the context of national helminth control programs (Publications)
1994, the prevalence of S. stercoralis, hookworm, A. lumbricoides, and T. trichiura decreased by 81.0%, 80.5%, 70.6%, and 48.6%, respectively. Infection intensities decreased by > 95% for all helminth species
