Antiprotozoal activity of (e)-cinnamic N-acylhydrazone derivatives (Publications)
antileishmanial activity (IC50 = 6.27 microM) when compared to miltefosine, the reference drug (IC50 = 0.348 microM). However, the elected compound showed an excellent selectivity index; in one case it was
Modelling the ecological niche of hookworm in Brazil based on climate (Publications)
Necator americanus) conditional on concurrent monthly values (rain/potential, evapotranspiration) of over 0.4. A second model, designated the gradient index, was calculated based on the monthly accumulation of
Cholesterol metabolites exported from human brain (Publications)
to be formed through reactive oxygen species, are similarly exported from brain at rates of about 0.1, 2 and 2mg/24h, respectively. Although not to statistical significance both GC-MS and liquid chro
Effects of filter choice in GT3X accelerometer assessments of free-living activity (Publications)
were established using linear regression models. RESULTS: Although Spearman correlations were high (r> 0.93), there were significant differences in minutes per day between filter options for non-wearing time
A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes (Publications)
physician-diagnosed, or use of diabetes medication or non-fasting glucose > 11.1 mmol/L or HbA1c > 0.065. Air pollution exposure was 10-year mean particulate matter
Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure (Publications)
exposure. METHODS: Genome-wide interactions of single nucleotide polymorphism (SNP) by ETS exposure (0 versus > /=1 h/day) in relation to the level of forced expiratory volume in one second (FEV1) were
Sesquiterpene lactones from <em>Vernonia cinerascens </em>sch. bip. and their <em>in vitro</em> antitrypanosomal activity (Publications)
against the mammalian cell line L6. Vernodalin (2) was the most active compound with an IC50 value of 0.16 microM and a selectivity index of 35. Its closely related congener 11beta,13-dihydrovernodalin (3)
Genetic diversity within diagnostic sputum samples is mirrored in the culture of <em>Mycobacterium tuberculosis</em> across different settings (Publications)
variant agreement within sputum-culture pairs, with a high correlation also in the variants' frequency (0.98). The combined analysis from five different settings and more than 100 available samples shows that
Genetic diversity within diagnostic sputum samples is mirrored in the culture of <em>Mycobacterium tuberculosis</em> across different settings (Publications)
variant agreement within sputum-culture pairs, with a high correlation also in the variants' frequency (0.98). The combined analysis from five different settings and more than 100 available samples shows that
Improved latrines minimally impact <em>Schistosoma mekongi </em>transmission in Mekong islands (Publications)
two rounds of MDA in the intervention villages reduced the prevalence of S. mekongi infection by 6.0% (from 28.6% to 22.6%; P
